- Cancer Biology & Biomarkers
- Chromatography & Mass Spectrometry
- Contract Research, Clinical Trials and Outsourcing
- Drug Discovery
- Drug Targets
- Flow Cytometry
- Informatics & Lab Automation
- Ingredients, Excipients and Dosages
- Microbiology & RMMs
- NIR, PAT & QbD
- Raman Spectroscopy
- Screening, Assays & High-Content Analysis
- Thermal Processing
- Events & Workshops
Bristol-Myers Squibb will win big with melanoma combination immunotherapy
23 June 2015 • Author: Victoria White
Data presented at ASCO 2015 by Bristol-Myers Squibb (BMS) suggests that its Opdivo/Yervoy combination of immunotherapies to treat metastatic melanoma will shape the therapeutic landscape once it is approved, says an analyst with research and consulting firm GlobalData.
According to Fenix Leung, DPhil, GlobalData’s Analyst covering Oncology and Hematology, data from BMS’ Phase III trial, CheckMate-067, which compared the combination of the Opdivo (nivolumab) and Yervoy (ipilimumab) regimen and Opdivo monotherapy with Yervoy monotherapy, stood out from the crowd because of the combination’s exceptional clinical efficacy.
As a consequence, with both Opdivo and Yervoy in its arsenal, GlobalData expects BMS to bag peak-year sales of $3.28 billion for both the monotherapies and the combination therapy across the eight major markets of the US, France, Germany, Spain, Italy, UK, Japan, and Australia in 2023.
Leung commented, “Overall, in terms of clinical efficacy, BMS’ immunotherapy combination is a clear winner in the melanoma treatment market. Should Opdivo’s competitors continue to focus on monotherapies, GlobalData expects them to have a hard time catching up to BMS’ combination therapy in this regard.
Companies are teaming up to create new combination melanoma treatments
“Currently, companies with immuno-oncology drugs, both marketed and pipeline, are teaming up in the hope of repeating BMS’ success. Merck is collaborating with Amgen, Dynavax, and Syndax to find a potential Keytruda (pembrolizumab)-containing combination for melanoma, while AstraZeneca has joined hands with Immunocore, Novartis, and Incyte.”
However, the analyst warns that unless these companies are able to develop an immunotherapy combination that is more efficacious and/or less toxic than BMS’ combination therapy, the New Jersey giant is likely to dominate the melanoma treatment market for a long time.
Leung continued, “Key opinion leaders interviewed by GlobalData are enthusiastic about the efficacy of the combination, and foresee it as the future standard of care. However, issues such as safety and high cost may restrict its sales.”
“The high cost of immuno-oncology therapies, especially when drugs are used in combination, is likely to result in a pushback from payers regarding the Opdivo combination regimen, opening the door for competitors, such as Merck’s Keytruda. In order to ease payers’ resistance, BMS may decide to offer a discount if Opdivo and Yervoy are used in combination,” the analyst concludes.
ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd Bachem AG Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) EUROGENTEC F.P.S. Food and Pharma Systems Srl IDBS JEOL Europe L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Panasonic Biomedical Sales Europe B.V. PerkinElmer Inc ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen Logistics