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New high purity grade of solvents for UHPLC-MS instrumentation

29 June 2015  •  Author: Thermo Fisher Scientific

New, exceptionally pure mobile phase solvents for ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) instruments have been designed to reduce background signal and minimize chromatographic interferences, facilitating accurate, sensitive and rapid trace analysis.

Fisher Chemical Optima UHPLC-MS solvents are high-quality, ultra-pure and designed to address the trace analysis needs of chromatographers performing state-of-the-art UHPLC. These new solvents are qualified for use with UHPLC/MS instrumentation, such as the Thermo Scientific Vanquish system.

The Optima UHPLC-MS solvents will be exhibited for the first time at the 63rd Annual American Society for Mass Spectrometry Conference, Booth 140 and at the Landmark Suite at the Renaissance Hotel in St. Louis.

UHPLC-MS is becoming the preferred technique to LC-MS in analytical laboratories, as it enables users to perform separations substantially faster, due to the innovative sub-2 micron columns. Submicron filtration also reduces the clogging of instruments, columns and check valves. A typical LC-MS gradient run can take up to 60 minutes, whereas UHPLC-MS can reduce this to just five minutes, while yielding a similar resolution without compromising flow rates.

Optima UHPLC-MS solvents are ideal for detecting trace amounts of analyte by MS/MS using either gradient or direct-flow analysis without baseline interference. Notably, Optima UHPLC-MS solvents provide a very low mass/noise level in both positive- and negative-mode ionization, minimal metal ion content and a low UHPLC-UV response using photo diode array detection.

“The quality of these high-purity solvents is linked directly to the sensitivity of high-end mass spectrometers, where parts-per-trillion levels of analyte can be detected by the signature product ion peaks, “ said Subhra Bhattacharya, senior product development scientist at Thermo Fisher Scientific. “The low signal–to-noise ratio achieved with the Optima UHPLC-MS solvents highlights the ultrahigh purity, resulting in minimal background interference.”

More information on the Fisher Chemical Optima UHPLC-MS solvents can be found by visiting www.fishersci.com/fisherchemical

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