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A selection of articles from European Pharmaceutical Review covering Raman Spectroscopy and Non-Destructive Material Identificiation:
29 February 2016 • European Pharmaceutical Review
Raman as a valuable tool in high-throughput screening; Use of Raman in analysing polymorphism in pharmaceutical drugs; Upcoming Raman calibration standards; Raman roundtable
29 February 2016 • Kerstin Barr, Product Manager, Thermo Fisher Scientific
In this article, Kerstin Barr, Product Manager for handheld Raman instruments at Thermo Fisher Scientific, comments on the revised tolerances...
22 October 2015 • Sulaf Assi, Sulayman A. Oladepo, Hui Wang, David Barona, Reinhard Vehring
Identification of counterfeit drugs using dual laser handheld Raman; Low-frequency shift Raman spectroscopy of pharmaceutical respirable powders; Raman Roundtable
3 July 2015 • Julien Villaumié and Hilary Jeffreys, Actavis
All regulatory agencies require that manufacturers accurately determine the amount of drug in a medicinal product so that the product can be deemed fit for patients. This forms part of batch release testing performed by Quality Control (QC) laboratories. The drug assay and/or content uniformity of the dosage units is typically performed by a wet chemistry technique that has not significantly changed in the industry for four decades. High performance liquid chromatography (HPLC) is widely used by laboratories for that purpose, and automated sample preparation systems are available. But there are drawbacks to these methods. This article explores how Transmission Raman now has the potential to revolutionise the release testing of pharmaceutical product in a QC laboratory...
5 November 2014 • Michael J. Miller, Deborah Gessell-Lee, Oliver Gordon, Joe Johnston, Neil Lewis, Jeanne Mateffy, Jeffrey W. Weber
Sulaf Assi discusses the investigation of medicine quality using handheld Raman spectroscopy, a look at Raman hyperspectral imaging, plus Raman roundtable...
5 September 2014 • Dr. John H. Kalivas, Editor for the Journal of Chemometrics and Applied Spectroscopy.
In the pharmaceutical industry, it is necessary to control, in a tight range, the active pharmaceutical ingredient (API) content of products, e.g., tablets or other powder blends. Thus, the API content needs to be continuously monitored. Preferably, analysis for the API content should be in-line (on site) allowing rapid and efficient quality control. It is well documented that spectroscopic methods, such as near-infrared (NIR) and Raman, in conjunction with multivariate calibration processes, can meet these goals under controlled conditions...
10 April 2014 • Sara J. Fraser, Keith C. Gordon, Sigrid Pieters, Yvan Vander Heyden, Thomas De Beer
Raman spectroscopy in the study of pharmaceuticals: the problems and solutions to sub-sampling and data analysis
Conformational state analysis of proteins by Raman spectroscopy: univariate and multivariate methods
25 October 2013 • Sulaf Assi (Bournemouth University), Xiaolin Cao (Amgen Inc.)
Raw material identification using dual laser handheld Raman spectroscopy.
Raman spectroscopy in support of biotherapeutic production: applications in protein formulation and purification
Raman Spectroscopy Roundtable.
20 August 2013 • Chanda R. Yonzon, Atul Karande, Sai P. Chamarthy and Brent A. Donovan (Merck & Co. Inc)
Raman spectroscopy has emerged as the preeminent analytical tool for a number of applications within drug discovery and development. Advances in the instrumentation, sensor fabrication and data analysis have enabled the wider acceptance of Raman spectroscopy. In discovery, Raman spectroscopy is used to elucidate structural activity relationships and to optimise reaction conditions and associated parameters (such as polymorph and formulation screening) that impact scale-up required for the transfer of drug compounds from discovery to development.
24 October 2012 • European Pharmaceutical Review
An implementation perspective on handheld Raman spectrometers for the verification of material identity.
Portable Raman spectroscopy for pharmaceutical counterfeit detection.
Ask the Experts.
26 April 2012 • Clare Strachan, Senior Lecturer Pharmaceutical Sciences, School of Pharmacy, University of Otago
The use of Raman spectroscopy in pharmaceuticals has grown enormously since its appearance on the scene in the 1980s1-4. While typical Raman spectroscopy setups are able to provide chemical and physicochemical information about the sample on the bulk level, most solid samples in the pharmaceutical setting may not be assumed to be homogenous, and many critical quality attributes, such as drug release for example, depend on component distribution. Thus, obtaining chemically and spatially resolved information about pharmaceutical samples is pertinent. Since Raman microscopy imaging made its debut in the pharmaceutical setting, the range of pharmaceutical applications for which the technique has been used has continued to grow5-7. Briefly, Raman spectroscopy involves the detection of inelastic scattering of light associated with molecular vibrations. The resulting photons have a longer (Stokes scattering) or shorter wavelength (anti-Stokes scattering) than the incident photons. In the most common setup (with spontaneous Raman scattering), the Stokes effect is detected since it is stronger. Raman spectroscopy is related to (near- and mid-) infrared spectroscopy since both techniques probe molecular vibrations, but there are several practical differences, which are due to the different molecular phenomena behind Raman scattering (polarisability change during vibration) and infrared absorption (dipole moment change, for more detail see e.g.8,9,5 for a brief explanation). While near-infrared and mid-infrared micro - scopy may also be used to gain chemically and spatially resolved information about samples, Raman microscopy has some advantages which include:
24 October 2011 • Alain Hédoux, Klara Dégardin, Yves Roggo
Solid state transformations of APIS during manufacturing by Raman analysis of pharmaceutical molecules and dosage forms.
Detection, determination of chemical composition and chemical profiling of counterfeit medicines.
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