As a classically trained electrophysiologist, I shall always remember my first encounter with automated patch clamp at Essen Instruments in June 2002. Essen Instruments had just developed the IonWorks HT, an instrument that can record currents from 48 cells simultaneously and perform up to 384 recordings with a drug addition step in a single 45-minute experiment. This accomplishment coincided with the start of a revolution in the field of ion channel drug discovery.
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