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Issue 2 2007
Issue 2 2007 / 27 March 2007 / Lisa Timmons, Department of Molecular Biosciences, The University of Kansas, Hiroaki Tabara, University of Tokushima, Japan, Craig C. Mello, Howard Hughes Medical Institutes and Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts and Andrew Fire, Stanford School of Medicine, Stanford University
Introduction of double-stranded RNA (dsRNA) can elicit a gene-specific RNA interference response in a variety of organisms and cell types. In many cases, this response has a systemic character in that silencing of gene expression is observed in cells distal from the site of dsRNA delivery. The molecular mechanisms underlying the mobile nature of RNA silencing are unknown. For example, although cellular entry of dsRNA is possible, cellular exit of dsRNA from normal animal cells has not been directly observed.
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Tagged with: Andrew Fire, Craig C. Mello, Functional genomics, Hiroaki Tabara, Lisa Timmons, Stanford University, The University of Kansas, University of Massachusetts Medical School, University of Tokushima
Issue 2 2007 / 27 March 2007 / Claudio Carini, MD,PhD,FRCPath, F. VP of Translational Medicine, MDS Pharma
Biomarkers are useful characteristics to evaluate disease progress and targets of therapeutic agents. They are objectively measured and obtained by non-invasive procedures collecting readily accessible matrixes (Blood, CSF). Biomarkers should be easy to detect, specific and reproducible. Most importantly when detected early in the course of a disease they should be effective in predicating long term clinical response.
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Tagged with: Biomarkers, Claudio Carini, MDS Pharma
Issue 2 2007 / 27 March 2007 / EPR
Date: June 3-7, 2007
Location: Indiana Convention Center, Indianapolis, Indiana
Website: www.asms.org
55th ASMS Conference on Mass Spectrometry
The American Society for Mass Spectrometry (ASMS) was formed in 1969 to promote and disseminate knowledge of mass spectrometry and allied topics. Membership includes over 7,000 scientists involved in research and development. ASMS sponsors the Annual Conference on Mass Spectrometry that is attended by almost 6,000 scientists.
Tagged with: ASMS, Show Preview
Issue 2 2007 / 27 March 2007 / Kazuyuki Nakamura, M.D., Ph.D., Professor and Chairman, Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine
Protein chip technology is essential for high through-put functional proteomics. In this review the development of a novel protein tag consisting of five tandem cysteine repeats (Cys-tag) at C-terminus of proteins which was covalently attached to the surface of a maleimide-modified diamond-like carbon-coated silicon chip substrate is described.
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Tagged with: Kazuyuki Nakamura, Proteomics, Yamaguchi University Graduate School of Medicine
Issue 2 2007 / 27 March 2007 / Myles Fennell and John Dunlop, Neuroscience Discovery Research, Wyeth Research
High content screening (HCS) has now become integrated into all aspects of drug discovery from target identification and validation to hit generation and lead optimisation through to toxicological profiling. In neuroscience, the ability to perform automated neurite outgrowth and neuronal morphology screening has been a significant driver of HCS implementation. This approach has evolved significantly from relatively simple measures of total neurite length to detailed multi-parametric characterisation of neuronal morphology.
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Tagged with: HCS (High Content Screening), John Dunlop, Myles Fennell, Neuroscience Discovery Research, Wyeth Research
Issue 2 2007 / 27 March 2007 / EPR
Date: May 22-25, 2007
Location: Montpellier, France
Website: www.neurosciences.asso.fr
Brain briefings
The 8th Congress of the French Neuroscience Society will be held in Montpellier, France on May 22-25, 2007. For the first time, the meeting is organised together with another neuroscience society, the Spanish Neuroscience Society.
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Issue 2 2007 / 27 March 2007 / Chad E. Beyer, PhD, Discovery Neuroscience, Wyeth Research
Despite marked advances in our understanding of chemical transmission, many of the complex processes, namely, our appreciation of the varying roles of neurochemicals in disease etiology, are still being investigated. To aid in this exploration and to monitor the extracellular levels of neurochemicals in living tissue systems, techniques such as in vivo microdialysis are routinely used.
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Tagged with: Chad E. Beyer, Discovery Neuroscience, Mircodialysis, Wyeth Research
Issue 2 2007 / 27 March 2007 / Douglas S. Auld, James Inglese, Ajit Jadhav and Christopher P. Austin, NIH Chemical Genomics Center, National Institutes of Health, Bethesda, G.Sitta Sittampalam, Chahrzad Montrose-Rafizadeh and James E. Mcgee, Lead Generation & Lead Optimization Biology, Discovery Chemistry Research & Technology and Philip W. Iversen, Global Discovery & Development Statistics, Eli Lilly & Company
Industrial scale technologies developed and applied within the pharmaceutical industry for the purpose of drug discovery have recently been adopted by many research laboratories for the purpose of facilitating chemical genomics. Taking full advantage of these technologies will require education in high-throughput screening assay systems as well as new methods that exploit the capabilities of existing technologies.
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Tagged with: Ajit Jadhav, Chahrzad Montrose-Rafizadeh, Christopher P. Austin, Douglas S. Auld, Eli Lilly & Company, G.Sitta Sittampalam, HTS (High Throughput Screening), James E. Mcgee, James Inglese, Philip W. Iversen
Issue 2 2007 / 27 March 2007 / EPR
Late last year, Thermo Electron and Fisher Scientific merged to become Thermo Fisher Scientific, Inc., the world leader in serving science. European Pharmaceutical Review spoke to Marc Casper, vice president of Thermo Fisher Scientific and president of its analytical technologies group to discover the impact this has had on the industry.
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Tagged with: Industry Insight, Marc Casper, Thermo Electron, Thermo Fisher
Issue 2 2007 / 27 March 2007 / EPR
May 7-10, 2007
Congress Center Basel, Switzerland
www.miptec.com
10th Anniversary of MIPTEC 2007 – The leading European Event for Drug Discovery Technologies
In the last decade, MipTec has evolved as the leading event in Europe on enabling technologies in the drug discovery process with its scientific programme and the accompanying exhibition. The conference is ideally suited for both specialists and newcomers to the field and gives everyone an excellent opportunity to gain a relevant and updated view of this rapidly moving field. Its diverse session topics address the wide range of disciplines and activities that populate the landscape of modern pharmaceutical research, from the identification and validation of new targets up to the generation and optimisation of candidate drugs through both in silico and experimental biology approaches. Distinguished scientists from both academia and industry have chosen MipTec as the ideal forum to unveil new concepts and share their experience with colleagues from all over the world. In addition, MipTec is committed to being unrivalled in Europe for the vendor exhibition that offers every participant a unique opportunity to gather critical information to guide the acquisition of technologies, services, tools and hardware. MipTec promises its growing community to preserve and continue its tradition of incorporating scientific sessions on highly relevant, emerging fields in drug discovery.
Tagged with: MipTec, Show Preview
Issue 2 2007 / 27 March 2007 / Simon Gaisford PhD., School of Pharmacy, University of London and Michael AA O’Neill PhD., Department of Pharmacy and Pharmacology, University of Bath
Characterising the properties of a material, understanding how these properties change in relation to local environment and quantifying potential interactions with other species are facets central to any drug development programme. Not understanding and, more importantly, not controlling these factors can have serious consequences for a pharmaceutical, from irreproducible processing to poor bioavailability, product instability and, worse, patentability. Properties that may be characterised include solubility, dissolution rate, stability (in combination with other excipients and as a function of relative humidity and temperature) and per cent crystallinity (or amorphous content).
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Tagged with: Michael AA O’Neill, Simon Gaisford, Thermal Analysis, University of Bath, University of London
Issue 2 2007 / 27 March 2007 / Joydeep Ganguly, PAT Group Lead and Gerrit Vogel, Senior Engineering Manager, Talecris Biotherapeutics
This case study provides a comprehensive look at Talecris1 Biotherapeutics’ approach to PAT and automation followed by examples of PAT deployed on a bioprocess. It introduces the concept of integrated and scalable automation, provides a comparison of automation concepts and explains how the selected automation effectively supports initiatives such as PAT.
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Tagged with: Gerrit Vogel, Joydeep Ganguly, PAT, Talecris Biotherapeutics
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