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Night on Highway 128Dr. Kary Mullis Most people in molecular biology today are not old enough to remember pre-PCR. But try to do your job without it and you will see what a difference that simple little technique has made... |
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IDBS: Integrated frameworkNeil Kipling, Founder and CEO, IDBS We caught up with Mr Neil Kipling, founder and CEO of software giants IDBS, to discuss future prospects and products in advanced solutions software... |
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PAT: not a purpose in itselfPeter Van Broeck et al, Johnson & Johnson The process analytical technology guidelines have been a hotly debated topic within the pharmaceutical industry ever since they were made public in 2004… |
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Thermal analysis and calorimetry: latest developmentsDanielle Giron, Chemical Research & Development, Novartis Pharma AG, Basel, Switzerland Thermal analysis techniques cover all methods in which a physical property is monitored as a function of temperature or time, whilst the sample is being heated or cooled under controlled conditions… |
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Test method validation for cleaning validation samplesRichard Forsyth, Associate Director in Worldwide GMP Quality, Merck & Co., Inc Testing cleaning validation samples requires a validated method. The extent of validation is dependent upon the type of method employed… |
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Going paperless: is now the time?John Trigg, Director, phaseFour Informatics Over the past 40 years, the development of increasingly powerful computers has played a major role in the advancement of laboratory experimentation… |
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High Content Screening as improved lead finding strategyDr. Marjo Simonen et al, Novartis Institutes for Biomedical Reseearch, Basel HCS is based on subcellular imaging using automated microscopy, in combination with automated image analysis. HCS was first introduced over a decade ago as one of… |
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Personalised medicine: are we ready for the revolution?Claudio Carini, F.M.D., Ph.D., FRCPath, F. VP of TM at MDS Pharma et al, Altus Pharma The impact of biomarker technology and biomarker strategies in pharmaceutical development is still in its infancy; but the impact is already proving significant… |
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Antibody-based proteomics to study cellular signalling networksJan van Oostrum, Head of Business Development, Zeptosens The complexity of drug discovery faces many challenges; principally, the failure of drug candidates during the development process as a result of adverse effects or lack of efficacy… |
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RNAi Therapeutics for neurodegenerative dieaseMatthew JA Wood, University of Oxford The early 21st century has seen a revolution in RNA biology, bringing with it prospects for developing these RNA-based medicines for the growing… |
The role of chemokines in type 1 diabetesLut Overbergh, et al, Laboratory of Experimental Medicine and Endocinology (LEGENDO), Catholic University of Leuven Type 1 diabetes is an autoimmune disease, characterised by immune infiltration into the islets of Langerhans, resulting in the destruction of insulin producing b-cells… |
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