Exclusive workshop: Biochemical Assays for Screening

Date: 4 – 6 December 2012
Venue: European ScreeningPort, Hamburg, Germany

Taking place over three days at the European ScreeningPort facility in Hamburg, the workshop will offer attendees the chance to participate in practical sessions using the latest technology available from six of the top screening equipment / reagent vendors in the pharmaceutical industry.

Workshop topics include:

  • Choice of biochemical assay development projects: kinase, protease or histone deacetylase
  • Kinetic characterisation of enzymes
  • Km determination for substrates
  • IC50 determination for inhibitor, signal stability, choice of liquid handling and Zi
  • Aspects of adaption of assays for screening of a small molecule library (known drugs)
  • Data analysis and classifying compounds as Hits
  • Interferers
  • Validation of Hits selected from screening campaigns
     

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