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Issue 5 2009
HACH LANGE
The latest advancement in process analytical technology – The ANATEL PAT700 on-line TOC analyser
The new MET ONE 3400 Series portable airborne counter
Accurate, drift free, cost saving ozone sensor
Lab Automation
The changing role of automation in High Throughput Screening
Development and implementation of an automated compound screening activities facility
Lab Automation Roundtable
The changing landscape of automation in pre-clinical drug discovery
Issue 4 2009
Next Generation Sequencing
New DNA sequencing technologies: applications, promises and challenges for pharmacogenomics
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Synbiosis
Launch of New Automated Colony Counter and Zone Sizing System With Unique HD Imaging
Make Analysing the Potency of Flu Vaccines Ten Times Faster With ProtoCOL’s New SRD Zone Measurement Features
New OPKA Assay Application Features for ProtoCOL Ensure Speedy Analysis of Pneumococcal Vaccines
Danish Biotech Reduces Vaccine Testing Time from Two Days to One Hour Using a ProtoCOL System to Assess Vaccine Potency
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HCA
High Content Analysis approach for targeted gene silencing and probing nanoscale cell responses
High content screening and analysis
High Content Analysis Roundtable
Issue 1 2009
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Featured Subjects/Topics
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Issue 6 2008
General Laboratory Classified Directories
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Issue 5 2008
Stem Cells
Stem cell research and therapeutic innovation: not always a long-term perspective
Human Embryonic Stem Cells: Progress in culture and maintenance
Small molecule mediators of cell differentiation: Tools to generate tissue from stem cells for screening applications
Stem Cells Roundtable
Cellular reprogramming and its implications for therapeutic applications
Combining perspectives: Multiscale integration of Stem Cell research
2009: A landmark year for stem cells
HTS Classified Directories
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bioMerieux
bioMérieux Delivers New Clean Room Range for Sterility Testing
Issue 4 2008
Chromatin
Chromatin: cracking the chemical code
Oscar Trask
EPR Digital Issue 1 2008
Achim Kirsch
Marc Bickle
FAQs
Rainer Pepperkok
Yvonne Ibig-Rehm
Roderick L Beijersbergen
Peter O'Brien
GE Analytical Instruments
BD Biosciences
Perkin Elmer
Issue 3 2008
Biopharmaceutical
Peracetic acid in the study of rhIL-11 methionine oxidation
Toxicology
In vitro toxicity screening as pre-selection tool
Neurotoxicity in preclinical studies
Segregation of molecular mechanisms of genotoxicity and carcinogenicity across human, yeast and Salmonella species
About CIA
Paul French
Fred Wouters
Anthony Mitchell Davis
Syngene
Major Cancer Centre is using Dymension 2D Gel Analysis Software
US Research Centre uses 2D Gel Image Analysis Software
Dymension 2D Gel Analysis Software used at Prestigious Veterinary Institute to detect proteins associated with immunity to parasitic gastroenteritis in sheep
Pall Life Sciences
Carl Zeiss
Bruker Optics
Daniel Zicha
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Industry News
Symyx Appoints New President of High Productivity Research
Doris Hafenbradl joins BioFocus as Senior Director, Biology and Natural Products
Dr. Christian Müller to be appointed new CFO of Carl Zeiss Meditec
Avantium appoints Gunnar Staaf as CEO Pharma
ICON Central Laboratories Expands its European Facility to Meet Growing Demand
GSK chief Andrew Witty succeeds Arthur Higgins as president of EFPIA
Pharminox appoints Iain Ross as Chairman
Clavis Pharma appoints Olav Hellebø as Chief Executive Officer
Former US FDA Director Joins ISPE As Regulatory Affairs Advisor
Fluid Handling Specialist Diba Appoints Kevin Zheng as China Sales Engineer
Ira Isaacson, M.D., Joins Heidrick & Struggles’ Global Life Sciences Practice
ICON Announces Retirement of Mr. Bob Scott-Edwards
RTS Life Science Appoints Richard Carpenter as New Mid-Atlantic Sales Manager
Biota appoints new Director
US President Obama’s budget request includes $911 billion for HHS and $4 billion for FDA in FY2011
Medical Marketing Group Appoints New Chair
Amarin appoints Jan van Heek non-executive director
M&A – The trials and tribulations
Eurofins AvTech Laboratories Adds Michael D. Barron to Team
Remedying Consumer Trust – Pharma Execs Unite
Q Chip Ltd announces appointment of Tony Mills
Dr. Ludwin Monz becomes CEO of Carl Zeiss Meditec
Biocitech technology park appoints Jean-François Boussard as CEO
New face for MedilinkWM’s assisted living team
Protein Crystallisation
New opportunities for protein crystallisation
The current challenge
Procurement
More than just cost cutting
Project Management
Taking care of innovation
European Pharmacopoeia
Analysing the monographs
Microdosing
Tool for candidate drug selection
Drug Safety
In vitro safety pharmacology profiling
Electrophysiology
In vitro and in vivo techniques in CNS drug discovery
Clinical Development
Integration is key
Site Development
Investing in Bavarian biotechnology
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Effective secondary care teams
Strategic Alliances
Partnering for better science
Lyophilization
An ever-evolving technology
The current state of PAT in freeze drying
Terahertz Spectroscopy
New opportunities for understanding
Vaccine Technology
Maintaining vaccine security
Cellular Imaging
Cell-based imaging
HTS
Science in Seattle
Launching an HTS campaign to discover new antivirals
HTS technologies to facilitate chemical genomics
Pursuing hot targets in drug discovery
The role of HTS in eADMET profiling
Affinity-based screening
Collaborating to find new approaches to tropical disease
Setting new standards in Ultra HTS
Efficient HTS in the nanoliter range
Integration of miniaturisation technologies
Ion Channel Drug Discovery
Bottlenecks and potential improvements
Critical success
A new approach to ion channel hit identification
The road ahead and how to get there
Patch clamp electrophysiology steps up a gear
Cell Culture Automation
Is the dream becoming reality?
Platform technology for routine three dimensional cell culture
Next Issue
Functional Genomics
Is Pharma getting what it needs from RNAi?
RNAi therapeutics for neurodegenerative disease: challenges and prospects
Size does matter: macro ncRNAs and the regulation of imprinted gene clusters - Issue 1/08
MicroRNAs and their relatives – new avenues in biomedical research
The expanding world of small RNA: from germ cells to cancer
In vivo drug target validation using RNAi
How will MicroRNAs affect the drug discovery landscape?
RNAi: an attractive choice for future therapeutics
Inducible systemic RNA silencing in Caenorhabditis elegans
Cancer immunotherapy using RNAi
Assessing the current proteomics field
Genomics for the new biomedicine
A new field in biomarker discovery and target identification
Challenges in High-Content siRNA Screening
The right approach to human therapy
Small non-coding RNAs as therapeutics
A new approach to specify RNAi experiments
MitoCheck: checking mitosis
Czech out RNAi
Novel antisense drugs for micro-RNA therapeutics
HTS using siRNA libraries
Applications in target ID and validation
The promise and pitfalls
Target validation
Forging therapeutics from small interfering RNAs
RNAi therapeutics: addressing targets?
MicroRNAs for high-throughput functional analysis
Computational prediction of microRNA and targets
Detecting microRNA targets or siRNA off-targets using expression data
miRNA and viral infections in vertebrates
RNAi applications in biology and medicine
Next generation antibody therapeutics: Antibody fragments, dual-targeting strategies, and beyond...
RNAi screening in the era of high-throughput genetics
Ion Chromatography
Advances in fast ion chromatography
Metabonomics
Evaluating drug safety
Technology Transfer
Ten steps to success
Tablet Compaction
Die-wall stress measurement
Rheology
The future of process design
Raman Spectroscopy
RS coupled to separations
Applications in bioprocesses and biotechnology
The rise of Raman
Exploring new sources of raw material
Raman spectroscopic techniques for biotechnology and bioprocessing
Raman spectroscopy in pharmaceutical analysis
A sensitive and selective vibrational spectroscopy technique in life sciences
Receptor Binding
A powerful tool for drug discovery
Analytical Techniques
The increasing use of Microbial Genotypic Techniques for the Identification of Pharmaceutical Isolates
Pharmaceutical analysis in drug development
Pharmaceutical analysis in quality control
Outsourcing
Specialisation impacts the European Contract Research Services market
Contract Manufacturing Organisations poised for great opportunities
CROs as a strategic fit – the one stop shop for R&D services
Unlocking the potential of the Asian giants
An integral role for CROs
RFID Technology
A new challenge in the pharmaceutical supply chain
Microdialysis
Novel strategies for antidepressant drug discovery
Biomarkers
Biomarkers and the tumour microenvironment
Biomarkers in neurodegenerative diseases
Designing a program for early CNS development
Biomarkers of efficacy and safety
The promise of pancreatic beta cells
Applications in drug development
Biomarkers Roundtable
Biomarkers in CNS drug discovery and development - focus on molecular blood markers
Sleep changes as translational pharmacodynamic biomarkers
Applying statistical inference in genomics with evidence-based pathways: Towards elucidating new functional correlations of biomarkers
Freeze Drying
Spray-freeze-drying in the manufacture of pharmaceuticals
PAT for freeze drying: cycle optimisation in the laboratory
Lyophilization: cycle robustness and process tolerances, transfer and scale up
A significant comparison between collapse and glass transition temperatures
The determination of structural changes of biopharmaceuticals during Freeze-Drying using Fourier Transform Infrared Spectroscopy
Ion Channel Electrophysiology
Four years and counting for automation
Ion channel electrophysiology in pharmaceutical research
High throughput electrophysiology platforms as enablers
Clinical Trials
Roundtable: The future direction for clinical trials
Taking clinical trials into the future
Getting the balance right
Cell Line Optimisation
Maximising the efficiency and application of automated planar patch clamp electrophysiology
Protein Crystallography
Protein crystallography in drug design: current bottlenecks
Structural genomics, the practical way
Automated classification of crystallisation images
Streamlining with automation and robotics
Science through cooperation
Synchrotron radiation: current status and future landscape
Cleanrooms
Trends in pharmaceutical cleanroom technology
HVAC energy savings in the pharmaceutical industry
Maintaining a spore-free environment in the cleanroom
Cleanroom standards
Co-operation through certification
International standards: a tool for compliance
Microbiology
Microbiology/ Microbiologists – Where next?
Cutting edge technologies and their potential role in pharmaceutical microbiology
A “PAT” on the back for Rapid Microbiological Methods
The significance and detection of VBNC microorganisms
Are the needs of the pharmaceutical industry being met?
Polyphasic approach to microbial identification
The current market and future trends for RMM
Solutions for the next stage
Opportunities for Rapid Microbial Methods
Microbial detection in mammalian cell culture systems
Implementation, validation and registration
Implementation, validation and registration of rapid microbiological methods
Recent development in Rapid Microbiology Methods
A practical approach to microbial testing to support non-sterile product stability
Quality risk management and the economics of implementing rapid microbiological methods
Real-time environmental monitoring: PAT solutions using rapid microbiological methods
Concurrent Evaluation of both Compendial and Rapid Methods (ATP Bioluminescence) for Monitoring Water Quality in Pharmaceutical Manufacturing
Novel and emerging sterilisation technologies
Microbiological quality for non-sterile drug product for the 21st century
Article 1: The implementation of Rapid Microbiological Methods
Drug Discovery/Lab Automation
High throughput materials discovery “reducing product time to market”
Driving lab automation forward
The impact of automation on drug discovery
The state of industrial laboratory automation
Quo vadis, Laboratory Automation Education?
A roadmap for development
Merck & Co.’s automated compound distribution centre
The AstraZeneca ACMF
Applying automation in early drug discovery: lessons learnt and future perspectives
The role of liquid handling technologies in successfully executing screening campaigns
Product News
Major US University uses GeneGnome for Six Years In Important Academic Study to Elucidate Mechanisms of Cell Division
Freedom EVO® gives RIA workflows a boost
Copley Scientific introduces new inhaler product testing aid
Life Technologies’ SOLiD System Finds Mutations in Small Cell Lung Cancer Line
SANOFI AVENTIS and KNF Flodos cooperate on new SIMDOS development
Robust and reliable Variable Area Flowmeters
Quotient Evidence white paper discusses the role of biomarkers in metabolic syndrome
Chip-Man Technologies introduces Cell-IQ 2
New ProtoCOL 2 UV Imaging Accessory
CyGEL™ sets zebrafish screening method
ABB introduces new research grade FT-NIR spectrometer
Automation boosts sample preparation for next-generation sequencing
TTP LabTech launches NEW high-content contract screening service
New article describes PAT for automated pharma mill control
Sysmex FPIA-3000 from Malvern identifies oversized particles in inhaled products
Look into the Futura for bioreactors
New Investment Means UK First for Nampak Healthcare
Thermo Fisher Scientific Introduces Unique Automated Microplate Mover at LabAutomation 2010
Pfizer Receives FDA Approval for Prevnar 13™ for the Prevention of Invasive Pneumococcal Disease in Infants and Young Children
Malvern’s near infrared chemical imaging supports reverse engineering of pharmaceutical tablets for troubleshooting product failures
Bio-Rad’s CFX Automation System Enables Walk-Away, High-Throughput Real-Time PCR
G:BOX EF Imaging System used at Major Plant Breeding Centre
Integromics and TATAA Biocenter collaborate to offer
New FOSS NIR article: Monitoring Viable Cell Density in Bioreactors Using Near-Infrared Spectroscopy
Tecan launches new services for Australasia
Freeman Technology highlights relevance of the FT4 for DPI characterisation at RDD 2010
PCR
The role of chemokines in type 1 diabetes: as assessed by RT-PCR
Night on Highway 128
Analysis of microRNA expression by qPCR
The real-time reverse transcription polymerase chain reaction – treat with caution
Real-time PCR gene expression profiling
Quantitative PCR assays in clinical drug development
Real-time PCR: clinical applications
Gold standard
Making the lab workhorse run faster
Real-time quantitative PCR – opportunities and pitfalls
There is more to qPCR than the PCR reaction
Real-time polymerase chain reaction – towards a more reliable, accurate and relevant assay
Article 1: the importance of sample quality for qPCR
The Data Cave: A collaborative method for interpreting genomic data
Article 2: Reverse Transcription - a necessary evil
Article 3: qPCR Assay Design
Article 4: Optimisation of the PCR step of a qPCR assay
Article 5: qPCR data analysis - Amplification plots, Cq and normalisation
Article 6: qPCR data analysis 2 - Controls and Troubleshooting
Ex-vivo LPS stimulation model coupled with quantitative PCR and its multispecies application in immunonutrition
Personalised Medicine
Personalised medicine: are we ready for the revolution?
HCS
High content screening as improved lead finding strategy
Genome-wide High Content Analysis of cellular pathways
Automated workflow optimisation and assay development strategies for High Content Research Facility, Trinity College Dublin
Statistical techniques for handling high content screening data
Identifying human toxicity potential
Academic contribution to high-content screening for functional and chemical genomics
The handling and analysis of large scale high content screening data
Neuronal morphology screening as a tool in neuroscience drug discovery
Achieving the potential of HCS
A perspective from Eli Lilly and Co.
Carving a niche in the realm of drug discovery
Connecting HCS to CNS drug targets
A bright future for drug discovery and development
Support for lead optimisation and target validation
Getting a handle on neuronal behaviour in culture
High content imaging subpopulation analysis for phenotypic drug discovery
Utilisation of secondary screening
Live cell high content screening in drug development
Addressing kinetic applications in High Content Screening
Development of cardiac cell based assays for study of cardiac disease – in with the new by automating the old
High throughput and high content screening microscopy: A microscopy based guideline
Basics of image analysis in High Content Screening
Cancer biology where do we go next?
LIMS/ELNS
Going paperless: is now the time?
Implementation of an enterprise ELN: a case study
The right technology, at the right time
Interfacing LIMS with ELN
Information automation in R&D laboratories; past and future
Aseptic Processing
Test method validation for cleaning validation samples
Advanced Aseptic Processing: RABS and Isolator Operations
Disinfectant validation
The weakest link is getting stronger
Thermal Analysis
Thermal analysis and calorimetry: latest developments
Enthalpic efficiency and the role of thermodynamic data in drug development: possibility or a pipeline dream!
A new era for microcalorimetry in drug development
Calorimetry for amorphous content quantification
ITC: affinity is not everything
Calorimetry for polymorph detection
Essential techniques for development
SCTA for pharma
Why is thermal analysis important to the industry?
Fast-scan differential scanning calorimetry
Application of DSC and MDSC in the development of freeze dried pharmaceuticals
PAT
PAT: not a purpose in itself
PQLI – providing practical solutions
PAT: a comprehensive guide
The future direction of ASTM E55 Committee on manufacture of pharmaceutical products
An eight-step Six Sigma toll-gate approach to PAT implementation
The business benefits
Implementing Near Infrared Spectroscopy as a PAT tool in the biopharmaceutical industries
PAT in the pharmaceutical industry
PAT and design science
EuPAT: an initiative to promote progress in the science underpinning PAT
PAT and scalable automation for bioprocess control and monitoring
Pharmaceutical manufacturing – for now and the future
QbD and PAT – 2008 is the year it goes mainstream
PAT Roundtable: trends and issues
PAT for the product lifecycle of a biopharmaceutical product
Committee E55 – an update
Wyeth forges ahead
The role of PAT in biotechnology
A vision for the future
Process analysis and control for profit
Cost, knowledge and convenience: facing the facts
Mass Spectrometry: another tool from the PAT toolbox
A Pfizer perspective
Harbinger of change
PAT – reducing the cost of quality in consumer products manufacturing
Wyeth’s PAT variations submitted through the EMEA Worksharing Procedure
Quality by Design, Validation, and PAT: operational, statistical, and engineering perspectives
Key Aspects to a Successful Implementation in Pharmaceutical Manufacturing
From data to knowledge through smart Process Analytical Technologies (PAT) and process systems engineering
Applying PAT in Chemical Process Development
QbD and PAT: From Science to Compliance
Real-time NIR monitoring of pharmaceutical blending processes with multivariate quantitative models
Process Analytical Technology (PAT) in Freeze Drying: Tunable Diode Laser Absorption Spectroscopy as an evolving tool for Cycle Monitoring
Contributing to the Sustainability of the UK Chemicals and Pharmaceuticals Industries
Company Listings A-Z
Proteomics
Antibody-based proteomics to study cellular signalling networks
Proteomics in the pharmaceutical industry: is the analytical challenge just too large?
Future trends for proteomics
Proteomics – the frontiers and beyond
Biomarker discovery and validation in clinical proteomics
Stathmin immobilisation on a chip using an oligo-cysteine tag
Mass spectrometry-based proteomics: trends in tools and strategies
The role of phospho-proteomics in drug discovery and development
HUPO drives the creation of protein test standards
An essential role for the Michael Barber Centre
A showcase project for EU research
Structure, function, interaction
The future of proteomics
The human plasma proteome: A biomarker pool too deep to explore?
Amassing the latest in MS
Identification and prevalidation of safety biomarkers
The HUPO Brain Proteome Project
Meeting the challenge with a new facility
Plasma protein biomarker discovery
Initiatives from Spain
Easy access for the scientific community
A network of innovation from Canada
MALDI FT-ICR MS platform for proteomics: Rationale for an offline approach and optimised implementation
Accessing stem cells via proteomics
Quest for a new generation of biomarkers using quantitative proteomics
European PROSPECTS for proteomics and systems biology
Progress by the Proteomics Standards Initiative
Quantitative Proteomics for Systems Biology
Protein PEGylation: An overview of chemistry and process considerations
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Industry Insight: Applied Biosystems – the next generation of sequencing
Industry Insight: Biology and data capture in the life sciences industry
Industry Insight: United they stand
Industry Insight: The measure of success
Spin-outs come of age
Quality through collaboration
US universities unite
A co-ordinated approach to RNAi
Plugging the gap
Industry Insight: An interview with Søren Morgenthaler Echwald
Siemens: innovation, industry and implementation
Expo sets a new standard in PAT implementation
Industry Insight: Exceeding innovation excellence
Addressing unmet needs
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