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Analytical techniques - Articles and news items


New ProtectionPlus module for 21 CFR Part 11 compliance with HORIBA Raman systems

Supplier news / 23 October 2015 / HORIBA Scientific

HORIBA Scientific, global leader in Raman spectroscopy systems for over 50 years, announces the release of their new ProtectionPlus module for the acclaimed LabSpec 6 Spectroscopy Suite…

HPLC Congress 2016- Exploring the Boundless Analytical Techniques

HPLC Congress 2016- Exploring the boundless analytical techniques

Supplier news / 16 September 2015 / HPLC

Microanalysis which is critical in today’s research is ushered by boundless analytical techniques, the major one being HPLC…

FIGURE 1 Parties involved in the biomarker discovery and validation process. Medical Science is responsible for sample collection, pre-classification and storage in biobanks. Analytical Chemistry is responsible for developing sample preparation protocols and analytical platforms both for comprehensive biomarker discovery on low numbers of samples as well as for the targeted validation in large sample cohorts. Bioinformatics is responsible for performing the data pre-processing and statistical analysis as well as the validation of data and clinical information provided by the analytical and medical partners. A close collaboration and information exchange is essential for the success of biomarker research

Discovery and validation of protein biomarkers

Cancer Biology, Issue 3 2012 / 10 July 2012 / Péter Horvatovich & Rainer Bischoff, Analytical Biochemistry, Department of Pharmacy, University of Groningen

Biomarkers are biological characteristics that are objectively measured and evaluated as indicators of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention. Biomarkers can be used to determine disease onset, progression, efficacy of drug treatment, patient susceptibility to develop a certain type of disease or predict efficacy of treatment at a particular disease stage. Protein molecular biomarkers are particularly popular due to the availability of a large range of analytical instrumentation, which can identify and quantify proteins in complex biological samples. Proteins are key compounds in biosynthesis, cell, tissue and organ signalling and provide cell and tissue structural stability in living organisms. The primary protein sequences are encoded in the genome; however, their complex posttranslational modifications (PTMs) and three dimensional structures are fairly unpredictable from genomic information. In this mini-review, we will provide an overview of the current state, challenge and important aspects of protein biomarker discovery and validation…

Pharmaceutical analysis in quality control

Industry Focus 2008, Past issues / 7 April 2008 /

Pharmaceutical analysis in drug development mainly focuses on methods to identify and quantify potential new drug candidates, determine purity, identify by – products and degradation products in compatibility and stability studies, and to determine the drug substance’s fate in the organism. Challenging tasks like these require sophisticated techniques, dedicated equipment and methods operated by highly skilled staff, often with a good academic background.

Pharmaceutical analysis in drug development

Industry Focus 2007, Past issues / 7 April 2008 /

It is clear that pharmaceutical analysis plays a very important supporting role in drug development. Already during the conception of a candidate drug, for example by chemical synthesis, suitable analytical means are required to determine the identity and purity of the compound. Subsequent studies performed on candidate drugs with the aim of establishing the pharmacological, toxicological and therapeutic characteristics of the candidate drug vastly rely on bioanalysis.


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