Chris Taylor - Articles and news items

Progress by the Proteomics Standards Initiative

Issue 1 2009, Past issues / 7 February 2009 /

There are compelling reasons for regularising the capture and description of proteomics data. Adhering to community-consensus specifications for the annotation of data sets can increase confidence in results and the conclusions drawn upon them, and supports data re-use; working with standard formats and vocabularies can raise efficiency and facilitates sophisticated approaches to data handling and analysis. The Human Proteome Organisation’s Proteomics Standards Initiative (HUPO PSI) is a standards generating body comprising diverse members of the proteomics community and related trades. It develops reporting guidelines, data formats and vocabulary terms with which to describe the components of a proteomics experiment. This article briefly explores the benefits accruing to the use of reporting standards, for academics and for those in a commercial setting; describes HUPO PSI, its products and the status quo with respect to compatible tools and databases; and closes by pulling back to consider multi-domain investigations in the life sciences.

The HUPO Brain Proteome Project

Issue 1 2006, Past issues / 2 February 2006 / Kai A. Reidegeld, Michael Hamacher, Helmut E. Meyer, Christian Stephan; MPC, Medical Proteom-Center, Ruhr-University of Bochum, Martin Blüggel, Gerhard Körting, Daniel Chamrad, Christian Scheer; Protagen AG, Herbert Thiele; Bruker Daltonik GmbH, Chris Taylor, Michael Müller, Rolf Apweiler, Philip Jones; EBI, European Bioinformatics Institute, Lennart Martens; Department of Medical Protein Research, Ghent University

The proteome analysis started by the Human Proteome Organization (HUPO)1 is the second big international consortium project after the sequencing of the human genome by the Human Genome Project (HUGO)2. The aim of the HUPO Brain Proteome Project (BPP)3 is to derive in depth knowledge of the brain from analysing samples with state-of-the-art proteomics techniques.


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