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European Molecular Biology Laboratory (EMBL) - Articles and news items

NEB® launches new NEBNext® Ultra™ II Kit for NGS Library Preparation with as little as 500 pg of input DNA

NEB® launches new NEBNext® Ultra™ II Kit for NGS Library Preparation with as little as 500 pg of input DNA

Supplier news / 4 November 2015 / New England BioLabs, Inc.

New Ultra II technology addresses lower input amounts and challenging sample types for Illumina® next generation sequencing systems…

Tecan automation greatly increases speed of protein complex production

Supplier news / 1 April 2010 /

ACEMBL is the first fully automatable pipeline for the production of multi-protein complexes, developed by researchers at the EMBL on the Freedom EVO® platform from Tecan…

Detecting microRNA targets or siRNA off-targets using expression data

Issue 6 2008, Past issues / 3 December 2008 /

Recently, small RNAs such as microRNAs (miRNAs) have been demonstrated to be important regulators in both plants and animals. In animals miRNAs act as translational repressors of target genes through a combination of inhibition of translation and mRNA destabilisation. These molecules have been implicated in a multitude of diseases, including cancer and represent promising candidates for both diagnostics and therapeutics. While substantial progress has been made in the detection, sequencing and profiling of miRNAs, accurately delineating their targets remains difficult. Purely computational approaches hold much promise, yet they still suffer from over-prediction. In this article we will describe alternative approaches that utilise computational analysis combined with gene expression data to better detect miRNA effects and their targets. In particular we will describe Sylamer1 a new tool for the detection of miRNA targets and siRNA off-target effects from expression data.

Genome-wide High Content Analysis of cellular pathways

Issue 1 2008, Past issues / 23 January 2008 /

Creating the molecular tools to combat human disease and infection remains the cornerstone activity of the pharmaceutical industry. The methodologies employed to discover new drugs has continually evolved as new biological techniques have emerged1; nevertheless the development of each novel compound is still only realised after many years of careful research, and a detailed analysis […]

 

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