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John Comer - Articles and news items

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New instrument for automated biorelevant biphasic dissolution and solubility testing

Supplier news / 23 October 2013 / Sirius Analytical Instruments Ltd

Sirius Analytical Instruments Ltd announces the launch of a new product, the Sirius InForm…

Industry Expert Panel

Issue 1 2013 / 21 February 2013 / Expert Panel

Welcome to European Pharmaceutical Review’s Industry Expert Panel. We have assembled a panel of authoritative voices from the pharmaceutical industry to speak on a wide range of issues that affect this industry, sharing their expertise and insight with our readers.

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Sirius Analytical product launch: surface dissolution imaging for real-time visualization of dissolution phenomena

News, Supplier news / 10 January 2013 / Sirius Analytical Instruments Ltd

Sirius Analytical Instruments Ltd announces the introduction of a new product…

Under the Microscope: John Comer, Sirius Analytical

Issue 6 2012 / 18 December 2012 / Helen Bahia, Editor, European Pharmaceutical Review

John Comer, Chief Scientific Officer at Sirius Analytical, discusses particle size analysis and characterisation.

Sirius Analytical was founded in 1989 with the goal to become a world-class manufacturer of innovative instrumentation for chemical analysis. Today, Sirius Analytical makes instruments to measure the physicochemical properties of drugs, specifically pKa, logP, solubility and dissolution. The current gold standard for Sirius Analytical is the SiriusT3, a third generation physchem measurement system.

“When we were developing the SiriusT3, we knew that scientists had less sample weight available to make physchem measure ments, so we miniaturised key components to facilitate titration experiments in just 1.5 mL volumes,” explains John Comer, Chief Scientific Officer, Sirius Analytical. “This led to the greatest benefit of the SiriusT3; it makes pKa, logP and solubility measurements using quite small amounts of sample. We can measure pKa by the pH-metric technique using half a milligram of sample while we need only a few micrograms to measure pKa by UV. The other benefit of a third generation technology is that we learned a lot about how to improve performance from customers and users of the first two generations and all that experience is built into the SiriusT3.”

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Sirius Analytical product launch: Novel particle size analysis and digital image analysis combined

News, Supplier news / 22 October 2012 / Sirius Analytical Instruments Ltd

Sirius Analytical Instruments Ltd announces the introduction of a new product…

 

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