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Lab Automation - Articles and news items

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L is for Lab Automation

Blog, Z Homepage promo / 29 November 2016 / Niamh Louise Marriott, Digital Editor

L is for Lab Automation – the next instalment of our daily pharmaceutical alphabet bringing you up to date with all the latest research…

New trends in intelligent robotics in the laboratory

New trends in intelligent robotics in the laboratory

Issue 2 2016, Manufacturing & Packaging / 4 May 2016 / Dr. Patrick Courtney, tec-connection

While robotics systems have been useful tools in the laboratory for many years, most notably in the area of liquid handling, many tasks are still only automated to a small extent. At the same time a new wave of robotic devices is reaching the market – from robot lawn mowers to driverless cars, as well as smarter robots in manufacturing. These benefit from the latest advances in mechatronics, sensors and artificial intelligence algorithms. Many of these advances are taking place in Europe thanks to ambitious public funding programmes. This article highlights some of the latest advances in robotics, which have the potential to take laboratory automation, and the science it enables, to the next level…

automation

Demands in medical automation technology brings two prominent players close

Blog / 22 April 2016 / Snehal Chougule, Allied Market Research

Here, Snehal Chougule discusses Trajan’s recent acquisition of automation solution company, LEAP Technologies Inc…

Automating the development of aptamer-based biological tools with Tecan

Automating the development of aptamer-based biological tools with Tecan

Supplier news / 24 February 2016 / Tecan

The ARNA Laboratory in Bordeaux, France, is using DNA and RNA aptamers to develop novel tools for biological applications…

L.B.Bohle Maschinen + Verfahren GmbH

Continuous processing will require a change in mindset for controls and automation

Supplier news / 4 February 2016 / L.B. Bohle Maschinen + Verfahren GmbH

Continuous processing for secondary manufacturing in pharma is still one of the hottest topics currently discussed…

Phenomenex and Tecan to Co-Market Automated Sample Preparation Solutions

Phenomenex and Tecan to co-market automated sample preparation solutions

Supplier news / 8 September 2015 / Tecan

Phenomenex, Inc. and the Tecan Group (SIX Swiss Exchange: TECN) today announced a collaboration to co-market automated solid phase extraction (SPE) sample preparation solutions…

Sergio Chai

Laboratory Automation: Liquid handling devices in drug discovery: when, what, why?

Drug Discovery, Issue 6 2013 / 15 December 2013 / Sergio C. Chai, Asli N. Goktug and Taosheng Chen, High Throughput Screening Center, Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital

Liquid handlers are ubiquitous and essential tools in every aspect of the drug discovery arena. Innovations in the past few decades resulted in a sizeable array of devices. With so many choices, it is important to identify appropriate instrumentation for a particular screening strategy, which should be based on unique capabilities and limitations. Intense advances in the design of liquid handling devices have broadened the capabilities to screen larger collections of compounds at a faster pace with increased reliability and efficiency. These innovations drift towards miniaturisation, in large part to reduce cost and increase throughput. A wide selection of fluid handlers has been developed for every aspect of drug discovery, which incorporate different technologies for discrete functions. Although this segment focuses on instrumentation relevant to the screening of small organic molecules, the perspectives presented herein can be valuable in the handling of oligonucleotides or biologics…

RNAi_Europe

Putting the ‘fun’ into functional genomics: a review of RNAi genomewide cellular screens

Genomics, Issue 6 2012 / 18 December 2012 / Dr. Stephen Brown, Sheffield RNAi Screening Facility, Biomedical Sciences, University of Sheffield

As RNA interference (RNAi) enters its teenage years from the first critical observations, it has now reached a multi-billion pound industry. There are few research areas that have expanded as quickly and spectacularly as the field of RNAi. The potential of RNAi initially sparked a functional genomics gold rush. Different uses of this technology in genomewide screens have identified genes involved in fundamental biological processes. There are now hundreds of research papers reporting genome-wide screens using cell culture to investigate the building blocks of the cell. However tempting it may be to speculate that this technology could be the new magic bullet to all our research needs, especially after some of the previous successes, some basic aspects of the RNAi technology and screening process still need to be addressed and improved upon. This review will investigate the strengths and weaknesses of our current technology, suggesting improvements and highlighting some of the novel growth areas in this field.

Our foundations of cell biology rely upon an understanding of cellular pathways, the components of which have been investigated over the last 40 years or so. Recent embellish – ment of the pathways has been carried out using models in cell culture with RNAi technology1. Many techniques have been used to reveal the functions of core pathway proteins, but few have sparked the imagination like the RNAi screen with the potential to systematically knock down the expression of every gene in the genome.

Automation in the Pharmaceutical Industry

Trends in laboratory automation: From speed and simplicity to flexibility and information content

Informatics, Issue 3 2010, Past issues / 24 June 2010 / Fernando A. Ramon Olayo, Manager, GlaxoSmithKline

The pharmaceutical industry has significantly influenced laboratory automation trends in the past two decades. The need to screen large collections of chemical entities in a short time with minimised consumption of reagents has driven a strong demand of parallelisation, automation, simplification and miniaturisation solutions from the suppliers of instruments, labware and assay technologies. Currently, the levels of automation and miniaturisation seem to have reached a plateau and the new paradigms are flexibility and information content.

drug discovery & drug development

Implementation of appropriate assays and HTS technologies in drug discovery

Issue 2 2010, Screening / 9 May 2010 / Sheraz Gul, Vice President, European ScreeningPort GmbH

In this article, an overview regarding advances in assay formats for specific target classes and options that should be considered when considering hardware will be given. There has been a significant growth in the assay and automation technologies that are available for compound screening activities and it is essential to evaluate a variety of these before beginning a drug discovery program, the aims of these being to ensure the most relevant assay formats that are available are adopted.

The changing landscape of automation in pre-clinical drug discovery

Industry Focus 2010, Past issues / 22 February 2010 /

Over the past decade we have seen a significant realignment of activities associated with drug discovery and this will continue for a multitude of reasons. Within the pharmaceutical industry we have seen significant changes e.g. a decrease in the numbers of drugs that are being approved by the regulatory authorities and the looming expiration of patented drugs, both of which have an immediate and direct consequence on revenue streams. In light of these issues, the pharmaceutical industry is responding appropriately. These changes have included a re-assessment of the strategies being employed in the pre-clinical phase of drug discovery, some of which are discussed in relation to automation solutions.

Lab Automation Roundtable

Issue 6 2009, Past issues / 12 December 2009 /

Participants: Dr Gordon R Alton, President and CEO, Altonyx Consulting / Dr Scott Bowes
Scientist, Novartis / Dr Sheraz Gul, Vice President and Head of Biology, European ScreeningPort /
Chris Molloy, Vice President of Corporate Development, IDBS

 

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