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liquid chromatography mass spectrometry (LCMS) - Articles and news items

ROMIL launches new interactive website

Supplier news / 25 October 2016 / ROMIL

ROMIL is proud to announce the launch of its new website; an easy-to-use, interactive resource for laboratory professionals requiring high purity solvents, acids, reagents and reference materials. This user-friendly, comprehensive reference site has been redesigned from the ground up and optimised for PCs, tablets and smartphones, allowing straightforward browsing of the product catalogue…

Increasing Throughput and Sensitivity of LC-MS assays with a focus on MS optimisation and novel LC strategies

Webinars / 13 July 2015 / Sciex

Simplifying peptide quantification with automated optimisation of MRM transitions and advantages of Micro flow LC to maximise LC-MS performance…

Figure 1: Sample preparation techniques for mass spectrometry based pharmaceutical and metabolite analysis. The three approaches discussed in the paper are outlined: (Top) mass spectrometry imaging from dosed tissue sections, (Middle) liquid chromatography mass spectrometry of tissue extracts or plasma/serum samples, (Bottom) gas chromatography mass spectrometry of plasma/serum samples

MS-based methods for detection, quantitation and localisation of pharmaceuticals and metabolites in biological samples

Chromatography, Issue 6 2012 / 18 December 2012 / Tyler Greer, Department of Chemistry, University of Wisconsin-Madison and Lingjun Li, Department of Chemistry & School of Pharmacy, University of Wisconsin-Madison

Mass spectrometry is a powerful, multi-faceted technique capable of analysing pharmaceuticals and their metabolites in biological matrices. Although it is more commonly applied to proteins, peptides and lipids, an increasing number of studies use mass spectrometry based techniques to detect, quantitate and localise pharmaceuticals and their metabolites. The availability of functionally unique ionisation methods and preparative separation options coupled with the specificity and sensitivity of a mass analyser make mass spectrometry an attractive option in pharmaceutical studies involving biofluids and tissue. This review aims to provide a general description of the primary mass spectrometric and preparative steps used to analyse pharmaceuticals in biological systems…

Recent developments in the use of LCMS in process pharmaceutical chemistry

Chromatography, Issue 1 2012 / 28 February 2012 / Dr. Florence O. McCarthy, Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork

Liquid Chromatography Mass Spectrometry (LCMS) is a powerful technique that has recently undergone exponential growth in its application to pharmaceutical synthesis. This perspective will outline the general principles of LCMS, detail some recent approaches and the benefits to be derived from its use at an early stage of process development. Identification of the components in a mixture is the primary function of analytical chemistry and there are a range of techniques available. When the solution to this problem requires some structural identity, LCMS is the instrument of choice. Liquid Chromatography Mass Spectrometry is defined as the use of the separating properties of liquid chromatography combined with a detector capable of mass analysis (mass spectrometer: single quadrupole, triple quadrupole, ion trap, Time Of Flight, Q-TOF etc.). This combination may be configured in many ways, for a general scheme…