Nanoparticles - Articles and news items

Developing nanopreparation properties for use in anticancer medicines

Industry news / 15 March 2017 / Steve Bremer, Managing Editor

Tumour therapy, particularly in the case of multidrug resistant cancers, could be significantly enhanced by using siRNA to down-regulate the production…

Particle Works offers bespoke microencapsulation for drug development

Supplier news / 12 October 2016 / Particle Works

Particle Works – the nano- and microstructured material specialist – provides microencapsulation services for drug development applications, including controlled drug release, solubility enhancement or targeted drug delivery…

Stem cell nano drug delivery applications to treat diabetes

Stem cell nano drug delivery applications to treat diabetes

Drug Delivery, Issue 2 2016 / 4 May 2016 / Vishal Shahidadpury, Anjali Hirani and Yashwant Pathak - University of South Florida Health

Stem cell therapy is currently utilised in medicine for its application in tissue repair and regenerative medicine. Unique characteristics of stem cells, such as self-renewal and differentiation, allow its function to be applicable for therapeutic purposes. Nanotechnology and cell microencapsulation have been researched and used as a means to protect cells from innate immune responses while permitting targeted drug delivery, as well as for sustained release of therapeutic agents to specific organs or cells. This review will provide an overview of stem cells, the purpose of nanotechnology and various surface modifications of nanoparticles for enhanced drug delivery, as well as describe how stem cell therapy is used for type 1 and type 2 diabetes mellitus. Additionally, a specific application of nanoparticle encapsulation and human embryonic stem cells in achieving glycaemic control, as seen in type 1 diabetes-induced immune-competent mice, will be discussed…

Nanotechnology tackles problems with noninvasive glucose monitoring

Nanotechnology tackles problems with noninvasive glucose monitoring

Drug Delivery, Issue 2 2016 / 4 May 2016 / Andreas Thomas, Medtronic GmbH / Araceli Ramírez and Alfred Zehe, Universidad Autónoma de Puebla

For diabetes mellitus patients who treat themselves with insulin, the need to self-monitor blood glucose in order to establish their insulin dose is a major burden, and highlights the need to develop non-invasive glucose measurement technologies. Up until now, such non-invasive systems that also have adequate measurement performance under daily life conditions have not been available. However, nanotechnology has the potential to provide a solution. Traversing all scientific disciplines its nanoscale nature means that new functionalities and properties of materials can be created, which contribute to the development of innovative products and applications. Nanomedicine extends from the medical applications of nanomaterials to nanoelectronic biosensors, and there are even possible future applications of molecular nanotechnology. Indeed, nanoparticles’ use in medicine is leaping ahead. For example, both organic and inorganic artificial nanoscale materials may be introduced into the human body and assigned diagnostic functions…

Application note: Purification of nanoparticles by Hollow Fibre Diafiltration

Application note: Purification of nanoparticles by Hollow Fibre Diafiltration

Whitepapers / 18 January 2016 / Spectrum Labs

Hollow Fibre Diafiltration is rapid alternative to traditional methods of nanoparticle purification like ultracentrifugation. Diafiltration can be used to purify a wide range of nanoparticles including liposomes, colloids, magnetic particles and nanotubes…

Polyelectrolyte complexes as nanoparticulate drug delivery systems

Polyelectrolyte complexes as nanoparticulate drug delivery systems

Issue 3 2015, Manufacturing & Packaging / 3 July 2015 / Anita Umerska, University of Anger and Lidia Tajber, Trinity College Dublin

Polyelectrolyte complexes at the nanoscale (polyelectrolyte complex nanoparticles; PECNs) can be harnessed as drug delivery systems for a range of low molecular weight drugs as well as peptides and proteins. The mild method of manufacture of PECNs results in the protection of the loaded bioactive and the choice of polyions forming the carrier makes PECNs very flexible in the design of a range of medical and pharmaceutical applications. This paper presents the key characteristics of PECNs and developments in the area…

Syrris launches novel quantum dot synthesis system

Syrris launches novel quantum dot synthesis system

Supplier news / 2 June 2015 / kdm communications

Syrris, a world leader in chemistry product innovation, has launched the Atlas Nanoparticle System for the automated synthesis of quantum dots…


CPI is a key partner in H2020 consortium to develop Nanopharmaceuticals

Industry news / 11 November 2014 / The Centre for Process Innovation

The Centre for Process Innovation (CPI) is part of a consortium which will focus on the development and scale up of nanopharmaceutical production…

Micro Droplet Systems

Micro Droplet Systems provide seamless production of monodispersed droplets

Supplier news / 9 October 2014 / kdm communications

Dolomite Microfluidics, a sister company to flow chemistry specialist Syrris, has developed an innovative range of Micro Droplet Systems for automatic, seamless production of monodispersed droplets…

Nanoparticle synthesis benefits from award-winning Syrris batch and flow reactors

Supplier news / 22 September 2014 / kdm communications

Innovative batch and flow reactors from leading manufacturer Syrris are proving advantageous for a variety of nanoparticle applications, offering scientists working in the field numerous benefits…

Particle Resizing

Particle characterisation in drug delivery

Issue 4 2014, Manufacturing & Packaging / 5 September 2014 / Driton Vllasaliu and Ishwar Singh, University of Lincoln

The use of materials in nano-scale dimensions is proving to be a promising approach to overcome drug delivery challenges. ‘Nanomedicine’ technologies are gradually achieving commercial success and reaching the clinic. Sub-micron nanocarriers have the potential to ferry the therapeutic to its site of action and in this process overcome the biological barriers and achieve targeted drug delivery, controlled or stimuli-responsive delivery and protect the therapeutic from biological milieus. Many different types of nanocarriers have been described, including polymeric nanoparticles (NPs), liposomes, solid lipid NPs, micelles, dendrimers and metal NPs among other systems (the terms ‘nanomedicine’, ‘NP’ and ‘nanocarriers’ are used herein to describe all nanosystems). Of particular interest are nanocarriers with the ability to act selectively and target cell internalisation processes, guiding the therapeutic into subcellular regions. NP features important in dictating their drug delivery performance, including targeted delivery and cellular trafficking, are their size, shape and surface characteristics such as surface charge, chemistry and the distribution of ligands…

Gattefossé SAS

App Note: Gattefossé SAS – Investigating the lipolysis of lipid nanoparticles: impact on drug release properties

Whitepapers / 11 February 2014 / Gattefossé SAS

Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) are colloidal systems of interest for the delivery of poorly water-soluble drugs…

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