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Nuclear Magnetic Resonance (NMR) spectrometry - Articles and news items

Fully Automated Structure Verification of Organic Compounds by Combining High Resolution Accurate MS with NMR Data Analysis

Poster note: Fully automated structure verification of organic compounds by combining high resolution accurate MS with NMR data analysis

Whitepapers / 20 April 2016 / Bruker Daltonik GmbH

Here we describe a new approach which automates structure verification for (synthetic) chemists…

How to avoid residual solvent when drying reverse phase HPLC fractions and prevent the formation of gums and oils.

How to avoid residual solvent when drying reverse phase HPLC fractions and prevent the formation of gums and oils.

Supplier news / 26 February 2016 / Biopharma Group

Traditional concentration of reverse phase HPLC fractions to dryness in a Genevac HT evaporator is a fast and safe process…

Application note: Enhancing reaction understanding with online NMR reaction monitoring – application to chemical route development

Application note: Enhancing reaction understanding with online NMR reaction monitoring – application to chemical route development

Whitepapers / 11 January 2016 / Anna L. Dunn, Analytical Research and Development, Pfizer, Department of Chemistry, University of Wisconsin / Anna Codina, Bruker UK Limited / David A. Foley and Mark T. Zell, Analytical Research and Development, Pfizer

In this work, we demonstrate the complementarity of NMR and infrared (IR) spectroscopy and show the use of NMR to improve the understanding and robustness of the synthesis of an active pharmaceutical ingredient (API) precursor…

Fast quantitative 2D NMR for quantifying analytes in complex mixtures

Fast quantitative 2D NMR for quantifying analytes in complex mixtures

Issue 3 2015, NMR Spectroscopy / 3 July 2015 / Patrick Giraudeau, University of Nantes

Nuclear magnetic resonance (NMR) spectrometry is a major quantitative tool in pharmaceutical analysis, owing to its extremely high accuracy. However, absolute quantification in complex mixtures is often hampered by spectral overlap which considerably reduces the quantitative performance of NMR. Fortunately, new quantitative approaches based on two-dimensional (2D) spectroscopy have recently been proposed, and they are capable of determining simultaneously the concentration of multiple analytes in mixtures with an excellent trueness and precision. The development of fast acquisition strategies has considerably improved the applicability of these methods, which are particularly appealing for the study of biological mixtures, with promising applications in metabolomics and pharmaceutical studies…

Bruker Webinar Feature

Accelerating Pharma R&D using Mass Spectrometry and NMR

Webinars / 14 May 2015 / Bruker Daltonics

In this recorded webinar three experts from Bruker Daltonics and University of Dundee introduce novel MS and NMR solutions and its applications in pharmaceutical research…

NMR Spectroscopy

NMR spectroscopy: a superior tool for quality control of pharmaceutical products

Issue 5 2014, NMR Spectroscopy / 28 October 2014 / Torgny Rundlöf, Pharmaceutical Evaluator, Medical Products Agency, Sweden

Pharmaceutical products have to be of high quality with respect to a number of predefined attributes, e.g. identity and strength with respect to the active pharmaceutical ingredient (API) and the presence and levels of impurities. At least for smaller compounds, such quality control often involves chromatographic methods. The examples given in this work show that Nuclear Magnetic Resonance (NMR) spectroscopy provides similar but even more detailed quality-related information…

Gérald Remaud, Head of the EBSI Team, University of Nantes

NMR – Recent developments for isotope profiling

Issue 3 2014, NMR Spectroscopy / 3 July 2014 /

Fraudulent misrepresentation, substitution or imitation of premium products has always been a problem for both the regulatory authorities and the pharmaceutical industry. The task of finding and preventing counterfeit products is particularly challenging1,2. Several analytical techniques are available to help characterise pharmaceutical compounds: physical profile; X-ray diffraction; infrared spectroscopy; mass spectrometry (MS); liquid or gas chromatography; and Nuclear Magnetic Resonance (NMR) spectrometry…

 

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