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Sirius Analytical Instruments Ltd - Articles and news items

Paul Whittles takes the reins at Sirius Analytical!

Supplier news / 1 April 2016 / Sirius Analytical

Sirius Analytical are pleased to announce that Paul Whittles has been appointed as its new Managing Director…

Sirius inForm to be used by leading research group at Purdue University

Supplier news / 16 September 2015 / Sirius Analytical

The Sirius inForm measures the kinetics of dissolution, absorption, controlled supersaturation and precipitation, and accommodates multiple dosage forms and sample types…

Sirius unveils Sirius Scissor – the first in vitro model for the subcutaneous injection of biopharmaceuticals

Supplier news / 29 June 2015 / Victoria White

Sirius Scissor is an instrument designed to mimic the stresses a treatment experiences when transitioning from formulation conditions to a SC environment…

Sirius App Note - Controlled supersaturation experiments

App Note: Controlled supersaturation experiments to check the time that additives keep drugs in solution

Whitepapers / 8 January 2015 / Sirius Analytical Instruments Ltd

Controlled Supersaturation experiments provide a way to create supersaturated solutions which can then be monitored to determine the precipitation rate and the time when precipitation starts. This is illustrated using bifonazole, a basic drug with pKa of 6.0…

Sirius App Note

App Note: Controlled supersaturation experiments to check the time that additives keep drugs in solution

Whitepapers / 9 July 2014 / Sirius Analytical Instruments Ltd

Controlled Supersaturation experiments provide a way to create supersaturated solutions which can then be monitored to determine the precipitation rate…

Karl Box, Head of R&D, Sirius Analytical

Sirius Analytical interviewed at AAPS 2013

News, Supplier news, Videos / 13 November 2013 / Freddy White, European Pharmaceutical Review

Karl Box, Head of R&D, Sirius Analytical speaks to Freddy White at AAPS 2013…

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New instrument for automated biorelevant biphasic dissolution and solubility testing

Supplier news / 23 October 2013 / Sirius Analytical Instruments Ltd

Sirius Analytical Instruments Ltd announces the launch of a new product, the Sirius InForm…

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3rd Annual Dissolution Symposium on June 3-4 2013

News, Supplier news / 20 March 2013 / Sirius Analytical Instruments Ltd

The University of Bath, Department of Pharmacy and Sirius Analytical invite you to attend the 3rd Annual Dissolution Symposium…

Industry Expert Panel

Issue 1 2013 / 21 February 2013 / Expert Panel

Welcome to European Pharmaceutical Review’s Industry Expert Panel. We have assembled a panel of authoritative voices from the pharmaceutical industry to speak on a wide range of issues that affect this industry, sharing their expertise and insight with our readers.

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Sirius Analytical product launch: surface dissolution imaging for real-time visualization of dissolution phenomena

News, Supplier news / 10 January 2013 / Sirius Analytical Instruments Ltd

Sirius Analytical Instruments Ltd announces the introduction of a new product…

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Sirius Analytical and Paraytec enter into development and technology licensing agreement

News, Supplier news / 7 January 2013 / Sirius Analytical Instruments Ltd

“We are delighted to begin this strategic partnership with Paraytec…”

Under the Microscope: John Comer, Sirius Analytical

Issue 6 2012 / 18 December 2012 / Helen Bahia, Editor, European Pharmaceutical Review

John Comer, Chief Scientific Officer at Sirius Analytical, discusses particle size analysis and characterisation.

Sirius Analytical was founded in 1989 with the goal to become a world-class manufacturer of innovative instrumentation for chemical analysis. Today, Sirius Analytical makes instruments to measure the physicochemical properties of drugs, specifically pKa, logP, solubility and dissolution. The current gold standard for Sirius Analytical is the SiriusT3, a third generation physchem measurement system.

“When we were developing the SiriusT3, we knew that scientists had less sample weight available to make physchem measure ments, so we miniaturised key components to facilitate titration experiments in just 1.5 mL volumes,” explains John Comer, Chief Scientific Officer, Sirius Analytical. “This led to the greatest benefit of the SiriusT3; it makes pKa, logP and solubility measurements using quite small amounts of sample. We can measure pKa by the pH-metric technique using half a milligram of sample while we need only a few micrograms to measure pKa by UV. The other benefit of a third generation technology is that we learned a lot about how to improve performance from customers and users of the first two generations and all that experience is built into the SiriusT3.”

 

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