Spray Drying - Articles and news items

Spray drying – various challenges, one solution?

Issue 6 2016 / 13 December 2016 / Nikki Whitfield, Quotient Clinical

Spray drying is a proven, flexible and scalable process used within the pharmaceutical industry to address a wide range of formulation and drug delivery challenges. Its versatility has been proven through applications to both small chemical and biopharmaceutical drugs for product delivery via multiple routes of administration. The technique is used to address stability challenges associated with temperature-sensitive molecules such as proteins and peptides, as well as providing innovative solutions for particle size critical applications such as inhaled drug delivery. In addition, the technology is now a primary formulation strategy to address an increasingly prevalent challenge in the industry: the successful oral delivery of poorly soluble compounds.

Quotient Clinical

Quotient Clinical and Upperton announce a spray drying partnership to deliver integrated formulation development and GMP manufacturing programs for poorly soluble drugs

Supplier news / 4 May 2016 / Quotient Clinical

Quotient Clinical and Upperton have announced a partnership to address drug delivery challenges…

Spray Drying: Solving solubility issues with amorphous solid dispersions

Spray Drying: Solving solubility issues with amorphous solid dispersions

Issue 4 2015, Spray Drying / 3 September 2015 / Yin-Chao Tseng, Boehringer Ingelheim

Amorphous solid dispersions (ASDs) are increasingly being used as a means of improving bioavailability of poorly water-soluble compounds in research and development, and spray drying technology has been recognised as one of the useful methods to generate ASDs. Although the application of spray drying for the production of ASDs in the drug discovery stage is still limited, ASDs prepared with a small-scale spray drying process can be an effective approach to deliver high doses of poorly water-soluble compounds and to enhance their plasma exposure in in vivo studies for early drug discovery efforts. This article reviews the application of this technology for the production of ASDs in a single process, and the use of small-scale spray dryers to produce ASDs as early preclinical formulations using only milligram quantities of drug substances…

Spray Drying

Spray drying in the pharmaceutical industry

Issue 5 2014, Spray Drying / 28 October 2014 / Filipe Gaspar, Senior Director of Particle Engineering Services, Hovione

Spray drying is one of the most remarkable technologies currently to be applied to pharmaceuticals. It is a continuous process that converts, in a single step, a liquid feed into a powder and is an ideal process when precise attributes such as particle size, morphology and stability are required. This review describes the technology, current and future applications and how the present level of understanding and modeling tools enable a process development stage that is both lean and risk-free…

PAT Supplement 2013

Process Analytical Technology (PAT): In-depth focus 2013

Issue 6 2013, PAT & QbD, Supplements / 16 December 2013 / Morten Allesø, Anette Seo Torstenson, Mette Bryder and Per Holm, Chemical & Pharmaceutical Research (H. Lundbeck A/S), Anneleen Burggraeve, Tom Van den Kerkhof, Jeroen Geens, Lieve Bijnens and Mario Hellings (Johnson & Johnson)

Presenting a rational approach to QbD-based pharmaceutical development: A roller compaction case study
PAT for pharmaceutical spray drying
PAT Roundtable
Show Preview: IFPAC® 2014

Spray drying pharmaceuticals

Issue 6 2011, Spray Drying / 13 December 2011 / Mingshi Yang, Faculty of Pharmaceutical Sciences, University of Copenhagen

Spray drying is a widely used technical method to produce fine particles, coarse powders, agglomerates or granulates in various industries. The characteristics of the particles produced by this method can be controlled and the particle properties can be maintained as constant throughout a continuous operation. The product from this process can readily meet the product specifications that are most desirable for subsequent processing or direct application. Hence, it has been successfully applied in the pharmaceutical industry to process both primary pharmaceuticals like APIs and also the final pharmaceutical formulations. The aim of this review is to present current pharmaceutical applications of this method and share my perspectives from both an industrial and academic point of view. I hope that it can serve as inspiration for some peers in pharmaceutical field.

By definition, spray drying is the transformation of a feed from a fluid state into a dried particu – late form by spraying the feed into a hot drying medium1. The drying medium is typically air, but an inert gas, e.g. nitrogen, can be employed when the liquid is a flammable solvent or the product is oxygen-sensitive. It is a one-step, con – tinuous particle formation process involving drying. The feed can be a solution, suspension, emulsion, dispersion or even paste, and the solvent medium can either be aqueous or organic. The dried product from the process conforms to particles, powders, agglomerates or granules, and the form of which depends upon the physical and chemical properties of the feed, the dryer design and the operation conditions1.


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