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University of Kentucky - Articles and news items

ada-scid-gene-therapy

Gene to drugs: can expression be the key to new discoveries?

Genomics, Issue 1 2013 / 25 February 2013 / Esther P. Black, College of Pharmacy and Markey Cancer Center, University of Kentucky

Cancer treatment faces a conundrum: a growing lack of therapeutics with lasting effects. The low hanging fruit of the medicinal chemistry orchard seems to have been picked, and modification of existing anti-cancer therapeutics has produced only incremental rewards[1]. Thus, both pharmaceutical companies and academic researchers are left searching for new strategies that will yield novel, long-lasting therapies and methods to rationally utilise existing therapies, alone and in combination, to individualise treatment regimens. The search for novel anti-cancer therapeutics or novel uses for existing drugs can benefit from the maturity of pharmacogenomics to extract genomic information for identification of new targets and therapeutic strategies.

Applications of solid-state NMR spectroscopy to pharmaceuticals

Issue 1 2013, NMR Spectroscopy / 21 February 2013 / Eric Munson, Patrick DeLuca Endowed Professor in Pharmaceutical Technology, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky

Solid-state NMR spectroscopy (SSNMR) has emerged as an extremely powerful analytical technique for the characterisation of pharmaceuticals[1-5]. Despite its capability, SSNMR is still not used ubiquitously in the pharmaceutical industry. Several factors contribute to this, including cost and analysis time, but two of the major reasons are understanding the full capability of the technique and having access to the expertise necessary to acquire and interpret the data. In this article, the use of SSNMR to study small molecule pharmaceuticals and its application in preformulation, formulation and manufacturing stages of pharmaceutical development are studied. The basics of solid-state NMR spectroscopy will be described. In particular, the information content of a SSNMR spectrum will be highlighted, such as the chemical shift, line width and relaxation time. Specific nuclei will also be discussed, including the advantages of 13C, 19F, 1H and other less abundant nuclei. Finally, four applications will be highlighted, including polymorph identification, quantitation, amorphous characterisation and dynamics.

 

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