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Identification of peptides and proteins in suspected illegal medicinal products using MALDI-TOF-MS

26 February 2019 | By , ,

Matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry (MS) has proven to be an excellent technique for identification of illegally distributed peptides and proteins for human use. The identification of proteins is mainly based on peptide mass fingerprinting (PMF) – ie, the bottom-up approach – while the small proteins and…

European Pharmaceutical Review Issue 1 2019

22 February 2019 | By

In this issue we look at the challenges of shipping temperature-controlled products, the potential use of blockchain for pharma, and using MALDI-TOF for identification of peptides in suspected illegal medicinal products. The edition also includes articles on aseptic containment, legal advice on licensing negotiations and an In-Depth Focus article from…

Key packaging trends for 2019

21 February 2019 | By

Consumer demands, a focus on sustainability and recycling, and political uncertainty in the UK are just a few challenges the packaging market had to overcome last year. Nikki Withers speaks to Ron Yakubison, Director of Pharmaceutical Packaging Operations at Merck Manufacturing and Sriman Banerjee, Head of Packaging at GSK, who…

Rapid microbiological methods and the regulatory environment

23 January 2019 | By

Rapid microbiological methods (RMM) continue to gain acceptance within our industry and a number of companies have already realised significant gains in detection sensitivity, automation, throughput, time-to-result and return on investment (ROI) when they have replaced their classical methods with these alternative technologies.

The future of precision medicine

16 January 2019 | By

As part of EPR’s Women in Pharma series, Ruth March, VP and Head of Precision Medicine and Genomics at AstraZeneca, talks to Science Editor Dr Zara Kassam about decreasing the clinical risk associated with solid tumour biopsy, balancing a scientific career with family life and taking advantage of company initiatives…

Recent developments of Raman spectroscopy for the qualitative analysis of falsified and substandard medicines

2 January 2019 | By , , , , , , , ,

Quality medicines are essential to any healthcare system and are the final goal of any pharmaceutical manufacturer. Unfortunately, as stated recently by the World Health Organization (WHO), one in 10 medical products circulating in low and middle-income countries is either substandard or falsified (SF products).1 Although the exact prevalence of…