news
Biosensing technique promising for whole-genome detection
The bacterial detection method is robust and highly sensitive over a wide concentration range and does not require DNA amplification, research suggests.
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Polymerase Chain Reaction (PCR)
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Microfluidic device detects bacteria concentration from small sample volumes
A novel ultrasonic nanosieve enabled concentration of bacteria into a 1µL highly concentrated solution suitable for plate counting and PCR, according to research.
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Implementing a real-time PCR-based method for sterility release testing of ATMPs
23 December 2022 | By Sartorius
Dr Alexandra Mueller-Scholz, Sartorius, and Yasmin Heynen, Molecular Development at Labor LS, discuss rapid sterility testing for ATMPs using a real-time PCR-based method.
news
Swedish innovation agency invests in new ATMP QC method
A new project funded by Swedish innovation agency Vinnova, will help develop an AI-based quality control method for ATMP manufacturing.
article
Real-time PCR detection of S. aureus in pharmaceutical products
The contamination of pharmaceuticals by microorganisms represents a major threat to public health, not just in the USA and Europe, but all around the world. Pathogenic microorganisms cause morbidity and in some cases mortality when present in products.1,2 Spoilage due to microbial breakdown of formulations can affect potency and shelf…
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Formulation, Development & Delivery In-Depth Focus 2018
In this supplement: Real-time PCR detection of Staphylococcus aureus in pharmaceutical products contaminated with mixed bacterial cultures, and an ICH Q3C(R5) elemental impurities update.
news
Rainin TerraRacks™ help to put the focus on canine genetics
METTLER TOLEDO’s Rainin pipettes and TerraRack™ pipette tip racks are helping Paw Print Genetics in Spokane, USA, to offer a canine carrier screening service, enabling dog breeders to ensure the health of their animals...
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Infoholics reports growth for polymerase chain reaction market
The global polymerase chain reaction market is estimated to witness a compound annual growth rate CAGR of 9.91% during the forecast period 2017–2023...
whitepaper
Whitepaper: Bacterial identification database
This whitepaper examines the Eurofins Microbial Sequencing Index (EMSI) database which contains over 9,000 full gene sequences of type strains and explains why reliable analytical methods are so vital in microbiology...
whitepaper
Application note: Direct PCR from blood using Platinum SuperFi DNA Polymerase
This application note describes how researchers can successfully perform PCR from blood samples without DNA purification using Platinum SuperFi DNA Polymerase...
whitepaper
Whitepaper: Maintaining sample integrity with aerosol-blocking tips
In this whitepaper, find out more about maintaining sample integrity with aerosol-blocking tips...
news
New England Biolabs® launches NEBNext Direct™ Technology with Cancer HotSpot Panel
8 August 2016 | By New England Biolabs, Inc.
Novel target enrichment technology, compatible with low input amounts from challenging sample types, uses a one-day workflow...
whitepaper
Whitepaper: Bioanalytical support in the development of biologics
In this publication Imperacer® case studies demonstrate the advantage of broad assay range combined with excellent sensitivity for several Biologics on their way from R&D to clinics...
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Issue #6 2015 – Digital edition
In digital version of Issue #6 2015: Microbiology, Screening, PCR, Continuous Manufacturing, PAT, Regulation, and much more...
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MIQE compliance in expression profiling and clinical biomarker discovery
6 January 2016 | By Irmgard Riedmaier, Melanie Spornraft, Benedikt Kirchner and Michael W. Pfaffl, Technical University of Munich
Molecular diagnostics and biomarker discovery are gaining increasing attraction in clinical research. This includes all fields of diagnostics, such as risk assessment, disease prognosis, treatment prediction and drug application success control. The detection of molecular clinical biomarkers is very widespread and can be developed on various molecular levels, like the…
