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Raman In-Depth Focus 2018
In this issue: the applications of vibrational spectroscopy for analysing the molecular component of a solid sample, and Raman as a fast-growing tool for PAT/QbD
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Process Analytical Technologies (PAT)
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Issue #2 2018 – Digital Version
In this issue; recent developments in turning promising compounds into drug candidates, reviewing the latest trends in pharmaceutical microbiology and their implications, and a roundtable debate featuring the views of five industry leaders.
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NIR In-Depth Focus 2018
This In-Depth Focus on near-infrared spectroscopy considers analysis using an innovative SAR-DRM and explores advances in technology that have an application on PAT/QbD.
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Siemens and Perceptive Engineering combining software solutions for the pharmaceutical industry
Siemens AG and Perceptive Engineering Ltd announce a partnership which offers Perceptive’s PharmaMV and Siemens Simatic Sipat software products closely integrated to provide a versatile solution for advanced control and optimisation applications in both continuous and batch pharmaceutical manufacturing...
webinar
Total Organic Carbon (TOC) and conductivity for state of the art cleaning validation
13 February 2018 | By SUEZ
This webinar is designed to help companies understand that cleaning should be addressed as an ongoing process, including continuous monitoring to ensure removal of all product and cleaning residues and removal of any potential contaminants...
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Application Note: Raman-based endpoint detection of a heterogeneous etherification reaction
Regulatory guidelines, from the 2004 U.S. FDA PAT framework to ICH Q8, Q9, Q10 and Q11 documents, have brought a shift to pharmaceutical processes and manufacturing...
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Biopharmaceutical Development & Processing
This In-Depth Focus looks at QbD and PAT for cutting biopharma attrition rates as well as continuous freeze-drying technology for biopharma products...
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Application Note: Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing
Adoption of Quality by Design (QbD) principles, regulatory support of QbD, process analytical technology (PAT), and continuous manufacturing are major factors effecting new approaches to pharmaceutical manufacturing and bioprocessing...
news
Sperm-sorting device may improve IVF success
Women undergoing IVF may become pregnant with fewer treatment cycles thanks to a device that uses an obstacle course to select the fastest and healthiest sperm...
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The importance of particle size analysis
Particle size reduction is a fast and cost-effective answer to increasing the exposure of poorly soluble oral drugs by increasing surface area and thereby improving dissolution rate. This approach will only work for DCS IIa1 drugs where dissolution rate is the rate-limiting factor for absorption. This may be applicable to…
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Hot melt extrusion technology for continuous manufacturing
Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage formulations, including solid dose form, which is of particular importance…
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What do we need from PAT?
Pharmaceutical manufacturing in the modern era is facing unprecedented demands, including in-depth scrutiny of production methodology, and inefficiencies in current practices with respect to waste, energy usage and time management. Coupling this with increased complexity in the manufacture of newer products and the decline of blockbuster drugs, results in an…
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The importance of critical quality attributes in Quality by Design for rapid bioprocess development strategies
QbD and PAT could revolutionise the way biopharma industries operate by cutting down their attrition rates, which could drastically change their business model. This article considers the issues involved.
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Issue #6 2017 – Digital Version
This issue celebrates European Pharmaceutical Review's 21st birthday through 21 interviews with leading lights from across the pharmaceutical industry...
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Separations & Purifications In-Depth Focus
In this Separations & Purifications In-Depth Focus: Sample preparation - is it possible to have too much? Discover the value of better quality chemistry; Determination of glucosamine in food supplements by HILIC-ESI-MS; Applying simple PAT tools to crystallisation in process chemistry...
