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Ebook: Container closure integrity and deep cold storage

Posted: 3 February 2021 | | No comments yet

A holistic approach for ensuring container closure integrity of product requiring deep cold storage.

Live viral vaccines and gene and cell-based therapies sometimes require deep cold storage temperatures (-80°C down to cryogenic, -196°C) to maintain the activity and efficacy of the formulations. Studies have shown that these deep cold storage temperatures can introduce risk to the sealing performance of the packaging components. This eBook describes how rubust development work can be done in a holistic framework to ensure container closure integrity (CCI) during deep cold storage.

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