HEATMOS filter technology for depyrogenation tunnels – innovations for extreme conditions
Nippon Muki illustrates the superiority of its innovative HEPA filter as a tool for sterilising injectable containers during the manufacturing process.
In pharmaceutical manufacturing, stringent sterilisation processes are necessary to ensure the sterility and safety of injectable containers. Dry-heat depyrogenation tunnels require the use of high temperature HEPA filters in compliance with PIC/S GMP standards. Our 350°C high temperature H14 grade HEPA filter ‘HEATMOS’ is developed for this application and we have test data demonstrating its superiority.
Filters used in depyrogenation tunnel
The depyrogenation tunnel is divided into the infeed zone, hot zone and cooling zone, and filters of at least HEPA grade must be used in all areas (Figure 1). As the maximum temperature in many tunnels reaches 350℃, HEPA filters with heat resistance of up to 350℃ are required.
HEATMOS test data
Heat cycle test
The test simulated temperature changes in the depyrogenation tunnel, confirming the filter’s capability to maintain performance under thermal stress.
This filter underwent 300 heat cycles with air flowing, as shown in Figure 2. The filter was checked before and after this test to confirm whether there were changes in efficiency, pressure drop and appearance.
