HEATMOS filter technology for depyrogenation tunnels – innovations for extreme conditions
Nippon Muki demonstrates the performance advantages of its innovative HEPA filter for the sterilisation of injectable containers in pharmaceutical manufacturing.
In pharmaceutical production, robust sterilisation processes are essential to ensure the safety and sterility of injectable containers. Dry-heat depyrogenation tunnels require high-temperature HEPA filters that comply with PIC/S GMP standards. HEATMOS®, a 350°C high-temperature H14-grade HEPA filter, has been specifically developed for this application, with test data demonstrating reliable performance under extreme thermal conditions.
HEPA filters in depyrogenation tunnels
A depyrogenation tunnel consists of an infeed zone, a hot zone, and a cooling zone, with HEPA-grade filtration required throughout all sections (Figure 1). As temperatures within the hot zone can reach up to 350°C, filters must be capable of maintaining structural integrity and filtration efficiency at these elevated temperatures.
HEATMOS® performance testing
Heat cycle testing
Testing was conducted to simulate temperature fluctuations experienced within depyrogenation tunnels, verifying the filter’s ability to maintain performance under repeated thermal stress.
The HEATMOS® filter was subjected to 300 heat cycles with continuous airflow, as shown in Figure 2. Filtration efficiency, pressure drop, and physical condition were evaluated before and after testing to confirm consistent performance.
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