How thermal analysis can enhance pharmaceutical drug development

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This webinar discussed three core techniques to optimise drug development through assessment of a material’s stability, composition, impurities, humidity effects, and thermal properties.

Thermal analysis is an excellent tool to characterise pharmaceutical materials and obtain quality control data.

The webinar will provide a brief overview about the different thermal techniques available for fast material analysis: thermogravimetric analyser (TGA), sorption analyser (SA), and differential scanning calorimeter (DSC).

Our speaker explored several applications, including glass transition, melting & crystallisation, change in heat capacity, compatibility, thermal stability and hydrothermal stability.

For example, you will learn how to select a material based on its hydrothermal stability and check the compatibility of an API and carrier material based on its heat capacity measurements.

Key learning points:

  • Thermogravimetric analyser (TGA): determination of the thermal and oxidative stability, quantification of the composition, evolved gas analysis (EGA) to identify residual solvents, impurities, or decomposition products
  • Sorption analyser (SA): stability under humidity, detection of phase transformations under humidity, hygroscopic classification.
  • Differential scanning calorimeter (DSC): detection and quantification of amorphous and crystalline components, determination of purity, compatibility of active ingredient and carrier material, optimisation of freeze-drying processes.

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