Thorough quality control of nucleic acid drugs is important to ensure their safety and efficacy. In this application, an automated computer-aided workflow was used for highly efficient method development.
Reversed-phase ion-pair chromatography is a common technique for characterisation of oligonucleotides. A target oligonucleotide and five related impurities that have different sequences were used as a model sample of synthetic antisense
oligonucleotide. Full-length product (FLP), deletion sequences of n–1 (3’), n–1 (5’) and n–3 as shortmers, addition sequence of n+1 as longmer and PO were included in the sample mix.
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