Helen Bahia - Articles and news items

Under the Microscope: John Comer, Sirius Analytical

Issue 6 2012 / 18 December 2012 / Helen Bahia, Editor, European Pharmaceutical Review

John Comer, Chief Scientific Officer at Sirius Analytical, discusses particle size analysis and characterisation.

Sirius Analytical was founded in 1989 with the goal to become a world-class manufacturer of innovative instrumentation for chemical analysis. Today, Sirius Analytical makes instruments to measure the physicochemical properties of drugs, specifically pKa, logP, solubility and dissolution. The current gold standard for Sirius Analytical is the SiriusT3, a third generation physchem measurement system.

“When we were developing the SiriusT3, we knew that scientists had less sample weight available to make physchem measure ments, so we miniaturised key components to facilitate titration experiments in just 1.5 mL volumes,” explains John Comer, Chief Scientific Officer, Sirius Analytical. “This led to the greatest benefit of the SiriusT3; it makes pKa, logP and solubility measurements using quite small amounts of sample. We can measure pKa by the pH-metric technique using half a milligram of sample while we need only a few micrograms to measure pKa by UV. The other benefit of a third generation technology is that we learned a lot about how to improve performance from customers and users of the first two generations and all that experience is built into the SiriusT3.”

Under the microscope: Graeme Lowe, Catalent

Issue 4 2012 / 3 September 2012 / Helen Bahia, Editor, European Pharmaceutical Review

Graeme Lowe, Director of Development and Analytical Solutions at Catalent, discusses outsourcing pharmaceutical development and analytical solutions.


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