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TNO Quality of Life - Articles and news items

Drug-drug interactions: tools for drug transporter protein studies

Issue 4 2009, Past issues / 30 July 2009 /

Drug transporters are membrane proteins involved in the uptake or efflux of drugs by several tissues such as the intestine, liver, kidney and brain. They can have a significant impact on the pharmacokinetics of endogenous and exogenous compounds. Also, co-administered drugs or nutrients can influence the transporter activity which may lead to changes in the pharmacokinetics of drugs and, as a result, possibly to reduced efficacy or increased toxicity (so called drug-drug or drug-nutrient interactions). For this reason the regulatory authorities US Food and Drug Administration (FDA) and European Medicines Agency (EMEA) request data on the effects of novel drugs on transporter protein activity.

Target validation

Issue 2 2005, Past issues / 20 May 2005 / Jeroen DeGroot, PhD; Anne-Marie Zuurmond, PhD, Daniel Eefting, MD; Ruud A Bank, PhD; and Paul Quax, PhD.; TNO Quality of Life, Business Unit Biomedical Research

All diseases have a genetic component, whether inherited or resulting from the body’s response to environmental stresses such as viruses, toxins or trauma. The successes of the human genome project have enabled researchers to pinpoint errors in genes that cause or contribute to disease.

 

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