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European Molecular Biology Laboratory (EMBL)

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Detecting microRNA targets or siRNA off-targets using expression data

3 December 2008 | By

Recently, small RNAs such as microRNAs (miRNAs) have been demonstrated to be important regulators in both plants and animals. In animals miRNAs act as translational repressors of target genes through a combination of inhibition of translation and mRNA destabilisation. These molecules have been implicated in a multitude of diseases, including…

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Genome-wide High Content Analysis of cellular pathways

23 January 2008 | By

Creating the molecular tools to combat human disease and infection remains the cornerstone activity of the pharmaceutical industry. The methodologies employed to discover new drugs has continually evolved as new biological techniques have emerged1; nevertheless the development of each novel compound is still only realised after many years of careful…