View the full list of references supporting this article in European Pharmaceutical Review, Issue 02 2026.
References
1. Panjwani S, Wei H, Mason J. Artificial Intelligence and Machine Learning-Assisted Digital Applications for Biopharmaceutical Manufacturing. Biotechnol Prog. 2026;42(2):e70089.
2. Nagy B, Galata DL, Farkas A, Nagy ZK. Application of Artificial Neural Networks in the Process Analytical Technology of Pharmaceutical Manufacturing – a Review. AAPS J. 2022;24(4):74.
3. Wasalathanthri DP, Rehmann MS, Song Y, et al. Technology Outlook For Real-Time Quality Attribute and Process Parameter Monitoring In Biopharmaceutical Development – A Review. Biotechnol Bioeng. 2020;117(10):3182–98.
4. Fernández de Sevilla MT, Valero R, Menéndez B, et al. Comparative Evaluation Of Yolov8, Yolov11, And RT-DETR for Automated Microcarrier Colonization Assessment in Bioreactor Cell Cultures. Front Bioeng Biotechnol. 2026;14.
5. Férnandez de Sevilla MT. ATENEA: Automated Microcarrier Colonization Detection. [Internet] Github. 2026 [Cited 2026May]. Available from: https://github.com/manutfds/Automated-Microcarrier-Bioreactor-detection
6. Cross A. What Annex 22 Spells for AI in GMP Manufacturing. [Internet] European Pharmaceutical Review. 2026 Available from: https://www.europeanpharmaceuticalreview.com/what-annex-22-spells-for-ai-in-gmp-manufacturing/2135686.article
7. Di Cerbo V, Song HW, Herbst L, et al. Artificial Intelligence, Machine Learning, And Digitalization Systems in The Cell and Gene Therapy Sector: A Guidance Document from the ISCT Industry Committees. Cytotherapy. 2025;27(8):903–9.
8. Buckler RL, Kunkel EJ, Thompson ML, Ehrhardt RO. Technological Developments for small-scale Downstream Processing of Cell Therapies. Cytotherapy. 2016;18(3):301–6.
9. Lei X, He L, Zhao G. The Application of Artificial Intelligence In Cryopreservation: Technological Advances And Future Challenges. Cryobiology. 2026;122:105589.
10. Wang RZ, Liao YX, Wang TL, et al. Hybrid AI/ML-Mechanistic Framework Enables Intelligent Optimization of Commercial Biopharmaceutical Downstream Processing. MAbs. 2026;18(1).



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