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Excipient knowledgebase to optimise the formulation and dosing of drugs
Researchers have compiled a repository of clinical and in vitro data for excipients to enable their potential to interact with drugs to be modelled.
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Formulation
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FDA sets up Novel Excipient Review Pilot Program
Manufacturers can submit their novel excipients for FDA review under the voluntary Novel Excipient Review Pilot Program.
Whitepapers/App Notes/Posters
Application note: Methods in protein/peptide discovery and development
This application notes offers method optimisation tips for purification, concentration and formulation of proteins and peptides.
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Temperature stable microneedle patch successfully delivers DNA COVID-19 vaccine
A microneedle patch, which can be stored for >30 days at room temperature, safely delivered a DNA-based COVID-19 vaccine in mice.
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Could amphibian foam be the future of topical drug delivery?
According to researchers, amphibian foam from the nests of the túngara frog could revolutionise topical, vaginal and rectal drug delivery.
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3D printing – current pharmaceutical applications and future directions
3D printing has the potential to revolutionise the pharmaceutical manufacturing industry; however, few 3D-printed products have been approved since the first in 2015. In this article, EPR’s Hannah Balfour explores the technologies currently being evaluated for use in the 3D printing of pharmaceuticals, and the work of key market players…
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NMR spectroscopy to enhance biologic drug delivery and stability
Review shows nuclear magnetic resonance (NMR) spectroscopy has the potential to enhance biologic drug formulation, optimising delivery and bioavailability.
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Application note: USP <643> TOC limit changes
This application note addresses the TOC limit changes in USP for packaged water. The new limits account for varying container volumes.
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A Raman spectroscopy technique to reliably analyse hydrogels
Scientists show how a combined time-resolved Raman and fluorescence spectroscopy can be applied to provide reliable drug diffusion data for drug-hydrogel combinations.
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FTIR, NIR and Raman – advantages and disadvantages for protein characterisation
Here, EPR summarises a review of some of the benefits and disadvantages for spectroscopic techniques used to characterise the structure of therapeutic proteins in solid dosage forms.
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Application note: Improving solubility: Stabilising the amorphous state
With 16 reactors at 1mL, The Crystal16 enables scientists to determine solubility curves, assess dispersion stability and critical solution temperatures.
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Improvements in skin and nail drug delivery using nano formulations
It might be easy to dismiss non-life-threatening diseases of the skin or nail as trivial, but their impact on physical and mental wellbeing can be significant. Such diseases are obvious targets for topical treatments, but the lack of effective formulations means patients are often faced with the prospect of oral…
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Formulation, Development & Delivery In-Depth Focus 2021
Featured in this in-depth focus: why improving dosing accuracy with infusion pumps requires users to have a better understanding of the equipment and how nanomedicines could be instrumental in improving skin and nail diseases.
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European Pharmaceutical Review Issue 4 2021
In our latest issue, features explore the use of nano formulations to improve skin and nail drug delivery, how to take cell and gene therapies from concept to commercialisation and what strategies you can use to overcome interfering factors in LAL bacterial endotoxin testing. Also in this journal, find out…
Whitepapers/App Notes/Posters
Application note: Growing X-ray quality single crystals
Grow X-ray quality crystals to make ensure you aren’t losing useful chemical information. Access diverse crystallisation methods with the CrystalBreeder!