- Cancer Biology & Biomarkers
- Chromatography & Mass Spectrometry
- Contract Research, Clinical Trials and Outsourcing
- Drug Discovery
- Drug Targets
- Flow Cytometry
- Informatics & Lab Automation
- Ingredients, Excipients and Dosages
- Microbiology & RMMs
- NIR, PAT & QbD
- Raman Spectroscopy
- Screening, Assays & High-Content Analysis
- Thermal Processing
The Comet Assay – A valuable tool for Cancer Research
This webinar is now available to watch on-demand
About this webinar
Research into cancer diagnosis and treatment has been at the forefront of scientific discovery for most of the recent past. Many of the drugs designed to combat cancer target genomic DNA, effectively causing DNA damage within these cells which is then thought to be responsible for killing the cancer cell.
This webinar presents real-world methods and examples of how to monitor and assess DNA damage in these cells using the Comet Assay and an insight into the software used to carry out this analysis – Komet.
Dr. George D. Jones
Deputy Head of Department of Cancer Studies
University of Leicester
Dr. Jones leads the Radiation & Oxidative Stress (ROS) group, Dept. Cancer Studies, University of Leicester. The group’s research aims to elucidate mechanisms responsible for the deleterious effects of radiation and oxidative stress.
Dr. Orla Hanrahan
Dr. Hanrahan has worked with Andor Technology as an Application Specialist in Life Science for the past 5 years. Previous to this she completed a PhD in Biochemistry and managed a microscopy facility for 5 years.
About the presentations
1st Presentation: Dr George D. Jones
For radiation and many chemotherapeutic drugs, genomic DNA is the primary cellular target for their deleterious biological effects; indeed it is the DNA damage induced which is thought responsible for killing of the cancer cells.
To better understand, judge and improve treatment efficacy, the purpose of their research is to explore mechanisms to enhance these damaging interactions and to develop methods and biomarkers for the accurate measurement of DNA damage in vitro and in vivo.
In this presentation, Dr. Jones illustrates how they use the Comet assay to assess DNA damage in vitro and in vivo.
2nd Presentation: Dr Orla Hanrahan
Dr. Hanrahan presents the key features and benefits of Komet software for the acquisition and analysis of The Comet Assay. Komet is the most highly referenced Comet Assay analysis solution in research publications and is so versatile it can score comets either during a live acquisition using the many cameras it supports or from files that have been saved and need scoring and analysis.
This webinar is supported by Andor
Andor Technology Ltd (Andor) is based in Belfast, Northern Ireland and operates at the high-value end of the global scientific digital camera market. Andor was setup in 1989 out of Queen’s University in Belfast, and now employs over 400 people in 16 offices worldwide and distributes its products to 10,000 customers in 55 countries.
The founders of Andor, working in the Physics department of Queen’s University, Belfast, found that the cameras then available were inadequate for their demanding applications, so developed their own. After using them in various imaging and spectroscopic applications they found they were being requested by researchers in other departments in Queen’s and other universities. Andor was formed in 1989 to take advantage of these requirements.
The company has grown organically and is today the fastest growing company manufacturing high performance digital cameras. Andor Technology PLC was admitted to AIM on Friday 3rd December 2004 (the London Stock Exchange’s Alternative Investment Market – a global market for smaller, growing companies).
Andor acquired Bitplane AG, Zurich, Switzerland in 2009. Bitplane is the world’s leading interactive microscopy image analysis software company specialising in Medical and Life Sciences. Bitplane’s focus on 3D and 4D imaging complements Andor’s existing business, especially the rapidly growing microscopy systems division.
To strengthen the microscopy division further Andor acquired Photonic Instruments, USA, in 2010. Photonic Instruments developed the revolutionary Mosaic and Micropoint products and are the market leaders in fluorescence imaging and laser ablation for Confocal and Widefield microscopy.
In January 2014, Oxford Instruments, a leading provider of high-technology tools for industry and research announced the acquisition of Andor Technology. As a result of this acquisition, Andor will continue to focus on growing their existing core markets and will spearhead Oxford Instruments strategic expansion into the Nano-Bio arena.
ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd B&W Tek Bachem AG Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited Butterworth Laboratories Ltd CAPSUGEL NV Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) Eurofins BioPharma Product Testing EUROGENTEC F.P.S. Food and Pharma Systems Srl GE Analytical Instruments IDBS JEOL Europe Kaiser Optical Systems Inc. L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited Lonza MA Business Metrohm Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Ocean Optics Panasonic Biomedical Sales Europe B.V. Peak Scientific ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Viavi Solutions, Inc Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen Logistics