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Application Note: Instrumental method for quantitation of colour in drug solutions
15 January 2016 • Author(s): HunterLab
Measurement and validation of the European Pharmacopoeia (EP) Colour scale.
EP Colour is used to assign a colour rating to liquid samples indicative of the product quality. The original intent of using EP Colour was to improve colour communication over more ambiguous word descriptors such as ‘slightly yellow’ by visual comparison to a fixed set of 37 transparent EP liquid colour standards, all of which are yellow.
As defined in European Pharmacopoeia Method 2.2.2, the visual EP Colour Scale consists of three primary colour standard solutions (yellow, red and blue) combined with a dilute hydrochloric acid solution to make five standard colour solutions – B (brown), BY (brownish-yellow), Y (yellow), GY (greenish-yellow) and R (red) that are subsequently diluted with hydrochloric acid (10g/l HCl) to make 37 reference EP liquid colour standards – 9B, 7BY, 7Y, 7GY and 7R.
ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd B&W Tek Bachem AG Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited CAPSUGEL NV Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) Eurofins BioPharma Product Testing EUROGENTEC F.P.S. Food and Pharma Systems Srl GE Analytical Instruments IDBS JEOL Europe L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited MA Business Metrohm Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Ocean Optics Panasonic Biomedical Sales Europe B.V. PerkinElmer Inc ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Viavi Solutions, Inc Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen Logistics