- Cancer Biology & Biomarkers
- Chromatography & Mass Spectrometry
- Contract Research, Clinical Trials and Outsourcing
- Drug Discovery
- Drug Targets
- Flow Cytometry
- Informatics & Lab Automation
- Ingredients, Excipients and Dosages
- Microbiology & RMMs
- NIR, PAT & QbD
- Raman Spectroscopy
- Screening, Assays & High-Content Analysis
- Thermal Processing
- Events & Workshops
Lilly’s psoriasis drug Taltz to generate sales over $1 billion by 2022
11 May 2016 • Author: Victoria White, Digital Content Producer
Lilly’s psoriasis drug Taltz (ixekizumab) is set to generate sales in excess of $1 billion in the US and Europe by 2022 due to its high clinical efficacy and good safety profile, according to an analyst with research and consulting firm GlobalData.
As explored in GlobalData’s recent report on the psoriasis market, the last six years have seen an influx of novel plaque psoriasis treatments outside mainstay anti-tumour necrosis factor (anti-TNF) therapies. Indeed, Novartis’ Cosentyx, the first-to market interleukin-17A (IL-17A) inhibitor launched in 2015, has shown superior efficacy over other approved biologics, most notably the anti-TNF therapy Enbrel.
Alexandra Annis, MSc, GlobalData’s Analyst covering Immunology, states: “Taltz has a shared mechanism of action with Cosentyx, and GlobalData anticipates it could be used ahead of a TNF inhibitor in biologic- and/or TNF-naïve patients in the psoriasis space. Although it will be competing with Cosentyx, which has a significant first-to-market advantage, Taltz offers more convenient dosing.
“The recommended dosing for Taltz is an initial 160 milligrams (mg) subcutaneous (SC) injection followed by an 80mg SC injection once every two weeks for 12 weeks, then 80mg every four weeks. In comparison, 300mg of SC Cosentyx is administered once a week, followed by 300mg every four weeks. In this way, Taltz will hold an edge in the anti-IL-17A market for psoriasis.”
The threat of Valeant’s brodalumab
In terms of competition GlobalData believes Taltz may face within the anti-IL17 class, Valeant’s brodalumab may pose a threat, which is in pre-registration in the US and Europe for plaque psoriasis.
Annis concludes: “Although the drug has garnered safety concerns recently surrounding increased suicidal tendencies, brodalumab demonstrated clear superiority over Stelara in two head-to-head clinical trials, AMAGINE-2 and AMAGINE-3, and established itself as one of the most effective psoriasis drugs developed to date.
“Despite the competition, GlobalData anticipates Taltz will become a blockbuster therapy due to its exceptionally high clinical efficacy.”
ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) EUROGENTEC F.P.S. Food and Pharma Systems Srl IDBS JEOL Europe L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Panasonic Biomedical Sales Europe B.V. PerkinElmer Inc ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen Logistics