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Chromatography - Articles and news items

Pall Life Sciences launches the Cadence™ BioSMB Process System to enable fully scalable, continuous multi-column chromatography

Pall Life Sciences launches the Cadence™ BioSMB Process system to enable fully scalable, continuous multi-column chromatography

Supplier news / 5 October 2016 / Pall Life Sciences

Pall Life Sciences is pleased to announce the commercial launch of the Cadence BioSMB Process system single-use flow path, continuous multi-column chromatography system…

Clarity version 7.0

New version of Clarity Chromatography Software expands portfolio of controlled instruments and introduces new features

Supplier news / 2 June 2016 / DataApex

Clarity version 7.0 has the reorganized installation structure, which allows better access to data and a new robust system of custom units…

HPLC Congress 2016- Exploring the Boundless Analytical Techniques

HPLC Congress 2016- Exploring the boundless analytical techniques

Supplier news / 16 September 2015 / HPLC

Microanalysis which is critical in today’s research is ushered by boundless analytical techniques, the major one being HPLC…

HPLC: On-chip liquid chromatographic separation

HPLC: On-chip liquid chromatographic separation

Chromatography / 17 April 2015 / Makoto Tsunoda, University of Tokyo

High-performance liquid chromatography (HPLC) is a powerful separation technique due to its high accuracy, precision, versatility and robustness. In the development of pharmaceuticals, it is no doubt that LC is a key technology in the quality control of pharmaceuticals and pharmacokinetic studies and in the analysis of complex biological compounds in bio-samples for the clarification of the function of biological systems. Nowadays, pharmaceutical developments require that HPLC analyses are fast and efficient. However, reducing separation times in LC without reducing the separation efficiency requires generating higher resolving power per unit time while speeding separation times without lessening the quality of the separation enables important analytical information to be generated more quickly. To achieve these goals in LC, monolithic column, high-temperature LC, fused-core column and ultra high-pressure LC with sub-2µm particles packed into column have been developed. This review will focus on chip-based pressure-driven LC separation…

David Elder

Can HPLC assay methods really be considered quality critical tests?

Chromatography, Issue 4 2014 / 5 September 2014 / Dave Elder, GlaxoSmithKline and JPAG

Analytical method specificity is assessed using ICH (International Conference on Harmonisation) Q2 (2005). Although, certain methods are not specific enough for their intended purposes, they may have other advantages. Both titrimetric and UV (Ultra-violet spectroscopy) assays are non-specific, but have superior precision (ca. 0.1-0.5% RSD (Residual Standard Deviation)) compared with the corresponding specific HPLC (High Performance Liquid Chromatography) assay methods (>0.5% RSD)…

Figure 1 Distribution of drugs in vivo depends on various equilibrium and rate processes between compartments

Bio-mimetic chromatography to predict drug distribution in vivo

Chromatography, Issue 5 2010 / 29 October 2010 / Klara Valko, Analytical Chemistry, GlaxoSmithKline Medicines Research Centre

A major concern for the pharmaceutical industry is the high attrition rate (>90 per cent) of potential drug molecules failing during late stages of the drug discovery process. This may be due to lack of efficacy in the clinic, unexpected side effects or unfavourable pharmacokinetics. There is a need for new tools to predict the in vivo distribution of discovery compounds earlier in the drug discovery process, thus reducing the investment in molecules failing unexpectedly in later, more expensive stages of the drug development. There are many in silico prediction tools for estimating pharmacokinetic and toxicological effects of compounds based on their chemical structures or physico-chemical properties…

New phases for rapid ion analysis

Issue 1 2005, Past issues / 7 March 2005 / Dr Brett Paull and Prof. Pavel Nesterenko, Research Scientists, National Centre for Sensor Research, Dublin

Ion chromatography (IC) is currently used throughout chemical and pharmaceutical industries for the quantitative determination of inorganic and organic anions and cations in a variety of matrices from both raw materials to finished products. In most cases, suppressed IC is utilised, particularly for the determination of inorganic anions and this represents the current ‘state-of-the-art’ for […]


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