Freek Ariese - Articles and news items

A sensitive and selective vibrational spectroscopy technique in life sciences

Issue 6 2009, Past issues / 12 December 2009 /

At present, the relevance of Raman Spectroscopy (RS) as an analytical tool in pharmaceutical sciences is increasingly obvious. RS is a mode of vibrational spectroscopy based on inelastic scattering of laser light and, like infrared spectroscopy (IR), provides detailed molecular structure information (see Figure 1A). However, contrary to IR, it is applicable to aqueous samples and furthermore sample handling is minimal. It can thus provide information on compounds in their “natural” environment. To illustrate its applicability, RS can be used to study materials in situ, such as pharmaceutical tablets inside polymer containers1. It is also applied as a process analyser or a process analytical tool2. Because of its fast and non-invasive character, it is also very suitable for the fast identification of illicit or counterfeit drugs3,4.

RS coupled to separations

Issue 2 2006, Past issues / 24 March 2006 / Cees Gooijer, Freek Ariese and Reyer J. Dijkstra, Dept. of Analytical Chemistry and Applied Spectroscopy, Laser Centre Vrije Universiteit

Currently, Raman spectroscopy (RS) is rapidly becoming a mature analytical technique in the pharmaceutical world. Thus far, it is used almost exclusively in a stand-alone mode, since coupling with liquid separation methods hardly seemed realistic in practice. However, as outlined in this article, recent developments are quite promising and such combinations of techniques have a distinct potential.


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