Nicolas Abatzoglou - Articles and news items

Near Infrared (NIR) In-deptch focus 2013

Near Infrared Spectroscopy: In-depth focus 2013

Issue 1 2013, Near-infrared spectroscopy, Supplements / 18 February 2013 / Pierre-François Chavez, Charlotte De Bleye, Pierre-Yves Sacré, Eric Rozet, Philippe Hubert, Eric Ziemons, Nicolas Abatzoglou, Eddy Castellanos Gil and Ryan Gosselin

Validation methodologies of near infrared spectroscopy methods in pharmaceutical applications.
Evaluating the influence of hopper geometry on radial and axial concentration profiles in flowing granular mixtures.

‘Pharmaceutical Industry / University’ R&D collaboration on Process Analytical Technologies

Issue 2 2010, PAT & QbD / 9 May 2010 / Professor Nicolas Abatzoglou, Chair, PAT in Pharmaceutical Engineering, Department of Chemical and Biotechnological Engineering, Université de Sherbrooke

Process analytical technologies (PAT) are mature and well advanced in the classical chemical industry. Many successful industry/university R&D collaborations are aimed at the development of analytical methods and their application in process control. However, PAT in the pharmaceutical industry is a rather new field. It is precisely this latter reality that makes many scientists, scientists-engineers and other practitioners sceptical about the possibility and the usefulness of establishing similar R&D collaborations between industry and academia.

Real-time NIR monitoring of pharmaceutical blending processes with multivariate quantitative models

Issue 5 2009, Past issues / 9 October 2009 /

Process analytical technology (PAT) initiatives are now an integral part of developmental efforts in the pharmaceutical industry. Many technical and scientific papers and even dedicated sections appear regularly in several pharmaceutical manufacturing publications. They may be part of a quality by design (QbD) project to better identify and understand critical process parameters. The need and plus value of PAT is usually well-recognised and understood through establishment of the design space of a unit process. However, monitoring and control methodology and PAT protocols are still undefined, and there is no global consensus yet. It is on these grounds that ASTM started working groups focusing on the elaboration of standards in model building and process monitoring with PAT.


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