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Pharma whitepapers & application notes

Kaiser whitepaper

Whitepaper: Analysis of a Mammalian cell culture

Author: Kaiser Optical Systems,

In this free whitepaper we discuss real-time, in situ bioprocess understanding in accordance with the PAT initiative and comparison of Raman and NIR spectra of cell culture components...

Rigaku app note

Application note: Aseptic identification of polysorbates using handheld Raman

Author: Rigaku

Polysorbates are used in a variety of industries including food, cosmetics, pharmaceuticals and biopharmaceuticals – specifically in the manufacturing of parenteral medication and cell culture growth...

App Note Drug product identification using Handheld Raman

App Note: Drug product identification using Handheld Raman

Author: Rigaku

This Application Note from Rigaku discusses the use of Handheld Raman spectroscopy for raw material and excipient identification within the pharmaceutical industry...

App Note IDBS Screening

App Note: ActivityBase for results management in screening

Author: IDBS

The secure and robust management of intrinsically complex cell-based screening data is paramount to ensure confidence in results and subsequent decision-making. Read how ActivityBase can be used for effective results management in screening...

App Note CAMO PAT Success

App Note: PAT success

Author: CAMO Software

Read how CAMO Software is working in the PAT (Process Analytical Technology) space to offer customers market leading software solutions for PAT applications...

App Note - GE Healthcare

App Note: Evolving promising leads

Author: GE Healthcare

The precision of data from surface plasmon resonance (SPR)-based analyses, and the confidence with which results can be interpreted, is strongly coupled to the sensitivity of the SPR sensor. Biacore™ T200 system from GE Healthcare offers excellent sensitivity that enables detection of the lowest molecular-weight interactions and accurate measurements at very low concentrations. The system allows generation of high-quality data even when working with unstable and sensitive molecules such as membrane proteins...

How does the analysis of biomolecules benefit from UHPLC?

App Note: How does the analysis of biomolecules benefit from UHPLC?

Author: Evert-Jan Sneekes, Remco Swart and Mauro De Pra - Thermo Fisher Scientific, Germering, Germany

Ultra high performance liquid chromatography (UHPLC) provides improved separation speed, throughput, and sensitivity by employing stationary phase particles of around 2μm or smaller. UHPLC has found widespread use in the analysis of small molecules in pharmaceutical, food, and environmental areas. Are these analytical benefits also applicable to the separation of larger molecules, such as proteins and peptides? Biomolecules have, apart from their size, other differences to small molecules (e.g. charges, complex structures) that make the application of UHPLC less straightforward. This article discusses the rationale of using UHPLC in life sciences and demonstrate where the potential is. It also discusses the requirements needed for a true bio UHPLC system and shows examples of relevant biomolecule separations...

App Note Genedata - Analysis of Compound Combination Experiments

App Note: Analysis of Compound Combination Experiments

Author: Genedata

With recent improvements in automation and liquid handling, compound combination experiments can be executed at higher throughput than ever before. However, software tools have not kept up with this increase and often still require either a manual, percombination workflow or cover just the synergy calculation without the necessary pre-processing steps. In this application note we describe how compound combination experiments should ideally be analysed...

App Note: Ocean Optics - Raman Analysis of Pharmaceutical Ingredients

App Note: Raman Analysis of Pharmaceutical Ingredients

Author: Ocean Optics

A range of options is available for Raman analysis, including systems suitable for handheld, laboratory and educational applications. Systems typically include a spectrometer, laser, operating software and sampling accessories, while modular options are available for users to configure their own Raman systems. Setups are available for various wavelength ranges and resolution requirements...

Gilson App Note - Anthocyanin purification

App Note: Anthocyanin purification from blackcurrant with SCPC-100

Author: Gilson

The blackcurrant is the edible berry of a shrub, which usually grows to 1-2 meters and can be found in Northern/Central Europe and Asia. Anthocyanins are found in high concentrations in the fruit and give its characteristic dark purple color. Delphinidin 3-O-glucoside, delphinidin 3-Orutoside, cyanidin 3-O-glucoside and cyanidin 3-0-rutoside make up more than 97% of anthocyanin in the plant1. The crude extract is a complex matrix and the use of Centrifugal Partition Chromatography (CPC) enables purification of the targeted compound. 500mg of powder extract of blackcurrant was injected by CPC to purify anthocyanin...

Sirius App Note - Controlled supersaturation experiments

App Note: Controlled supersaturation experiments to check the time that additives keep drugs in solution

Author: Sirius Analytical Instruments Ltd

Controlled Supersaturation experiments provide a way to create supersaturated solutions which can then be monitored to determine the precipitation rate and the time when precipitation starts. This is illustrated using bifonazole, a basic drug with pKa of 6.0...

Detection of naturally occurring bacterial endotoxins in water samples - Figure 1

Whitepaper: Detection of naturally occurring bacterial endotoxins in water samples

Author: Johannes Reich (PhD Student, University of Regensburg), Karolina Heed (Director M&S, Hyglos GmbH) & Holger Grallert (Vice President R&D, Hyglos GmbH)

A comparison study using two different Kinetic Chromogenic Limulus Amebocyte Lysate (LAL) Assays and three different Endpoint Fluorescent Recombinant Horseshoe Crab Factor C (rFC) Assays...

 

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