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Pharma whitepapers & application notes

App Note IDBS Screening

App Note: ActivityBase for results management in screening

Author: IDBS

The secure and robust management of intrinsically complex cell-based screening data is paramount to ensure confidence in results and subsequent decision-making. Read how ActivityBase can be used for effective results management in screening...

App Note CAMO PAT Success

App Note: PAT success

Author: CAMO Software

Read how CAMO Software is working in the PAT (Process Analytical Technology) space to offer customers market leading software solutions for PAT applications...

App Note - GE Healthcare

App Note: Evolving promising leads

Author: GE Healthcare

The precision of data from surface plasmon resonance (SPR)-based analyses, and the confidence with which results can be interpreted, is strongly coupled to the sensitivity of the SPR sensor. Biacore™ T200 system from GE Healthcare offers excellent sensitivity that enables detection of the lowest molecular-weight interactions and accurate measurements at very low concentrations. The system allows generation of high-quality data even when working with unstable and sensitive molecules such as membrane proteins...

How does the analysis of biomolecules benefit from UHPLC?

App Note: How does the analysis of biomolecules benefit from UHPLC?

Author: Evert-Jan Sneekes, Remco Swart and Mauro De Pra - Thermo Fisher Scientific, Germering, Germany

Ultra high performance liquid chromatography (UHPLC) provides improved separation speed, throughput, and sensitivity by employing stationary phase particles of around 2μm or smaller. UHPLC has found widespread use in the analysis of small molecules in pharmaceutical, food, and environmental areas. Are these analytical benefits also applicable to the separation of larger molecules, such as proteins and peptides? Biomolecules have, apart from their size, other differences to small molecules (e.g. charges, complex structures) that make the application of UHPLC less straightforward. This article discusses the rationale of using UHPLC in life sciences and demonstrate where the potential is. It also discusses the requirements needed for a true bio UHPLC system and shows examples of relevant biomolecule separations...

App Note Genedata - Analysis of Compound Combination Experiments

App Note: Analysis of Compound Combination Experiments

Author: Genedata

With recent improvements in automation and liquid handling, compound combination experiments can be executed at higher throughput than ever before. However, software tools have not kept up with this increase and often still require either a manual, percombination workflow or cover just the synergy calculation without the necessary pre-processing steps. In this application note we describe how compound combination experiments should ideally be analysed...

App Note: Ocean Optics - Raman Analysis of Pharmaceutical Ingredients

App Note: Raman Analysis of Pharmaceutical Ingredients

Author: Ocean Optics

A range of options is available for Raman analysis, including systems suitable for handheld, laboratory and educational applications. Systems typically include a spectrometer, laser, operating software and sampling accessories, while modular options are available for users to configure their own Raman systems. Setups are available for various wavelength ranges and resolution requirements...

Gilson App Note - Anthocyanin purification

App Note: Anthocyanin purification from blackcurrant with SCPC-100

Author: Gilson

The blackcurrant is the edible berry of a shrub, which usually grows to 1-2 meters and can be found in Northern/Central Europe and Asia. Anthocyanins are found in high concentrations in the fruit and give its characteristic dark purple color. Delphinidin 3-O-glucoside, delphinidin 3-Orutoside, cyanidin 3-O-glucoside and cyanidin 3-0-rutoside make up more than 97% of anthocyanin in the plant1. The crude extract is a complex matrix and the use of Centrifugal Partition Chromatography (CPC) enables purification of the targeted compound. 500mg of powder extract of blackcurrant was injected by CPC to purify anthocyanin...

Sirius App Note - Controlled supersaturation experiments

App Note: Controlled supersaturation experiments to check the time that additives keep drugs in solution

Author: Sirius Analytical Instruments Ltd

Controlled Supersaturation experiments provide a way to create supersaturated solutions which can then be monitored to determine the precipitation rate and the time when precipitation starts. This is illustrated using bifonazole, a basic drug with pKa of 6.0...

Charles River whitepaper

Technical Sheet: Charles River Accugenix® MALDI-TOF enhancements for bacterial identifications enable improved root cause analysis

Author: Charles River

Library coverage is often a topic of discussion for microbiologists wanting to know what the impact or relevancy of the Charles River Accugenix® library databases is on the identification of environmental, EM or industrial microorganisms. As a contract laboratory service provider offering both sequencing (AccuGENX-ID®) and MALDI-TOF-based identifications (AccuPRO-ID® and the Axcess™ system), Charles River has the ability to compare reference libraries based on the microorganisms that we identify and analyze the reportable rates...

WITec 3D raman imaging-270

Whitepaper: Chemical characterisation of diverse pharmaceutical samples by Confocal Raman Microscopy

Author: WITec

Confocal Raman Microscopy (CRM) is extremely useful for drug substance design, for patent infringement and counterfeit analysis...

BW Tek whitepaper

Whitepaper: Sampling Guidelines for Handheld Raman Measurements; What You Need To Know

Author: Enrique Lozano Diz and Katherine Bakeev

As we see increased adoption of Raman Spectroscopy as the technique of choice for the rapid identification of materials, our guidelines tell you what you need to know...

Sirius App Note

App Note: Controlled supersaturation experiments to check the time that additives keep drugs in solution

Author: Sirius Analytical Instruments Ltd

Controlled Supersaturation experiments provide a way to create supersaturated solutions which can then be monitored to determine the precipitation rate...