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Pharma whitepapers & application notes

Whitepaper: Is it essential to sequence the entire 16S rRNA gene for bacterial identification?

Whitepaper: Is it essential to sequence the entire 16S rRNA gene for bacterial identification?

Author: Charles River

The biopharmaceutical industry, especially manufacturing facilities, needs to implement bacterial identification to avoid the occurrence of a problematic microorganism in the final product that could be harmful for the end user and detrimental to a company’s finances and reputation...

Application note: Attaining high transient titers in CHO cells

Application note: Attaining high transient titers in CHO cells

Author: Chao Yan Liu, Virginia Spencer, Ph.D., Shyam Kumar, Jian Liu, Henry Chiou, Ph.D., and Jonathan F. Zmuda, Ph.D.

Case study involving the use of the ExpiCHO™ mammalian transient expression system...

Application Note: In-line Raman spectroscopy for content uniformity

Application Note: In-line Raman spectroscopy for content uniformity

Author: Kaiser Optical Systems, Inc.

Raman monitoring of blended granule uniformity prior to tablet press...

Application Note: Minding your caps and tails – considerations for functional mRNA synthesis

Application Note: Minding your caps and tails – considerations for functional mRNA synthesis

Author: Breton Hornblower, Ph.D., G. Brett Robb, Ph.D. and George Tzertzinis, Ph.D., New England Biolabs, Inc.

This article discusses options for selection of reagents and the extent to which they influence synthesised mRNA functionality...

Application Note: MicroNIR PAT for blend monitoring

Application Note: MicroNIR PAT for blend monitoring

Author: VIAVI

This paper discusses how the MicroNIR PAT spectrometer was used to monitor the blend uniformity of a number of designed blends of commercially available coffee, sugar and creamer and to jointly assess the sensory preference of the blends in a way that is typical of the process used by a pharmaceutical company to better understand the powder blending operation in tablet manufacturing...

Application note: Purification of nanoparticles by Hollow Fibre Diafiltration

Application note: Purification of nanoparticles by Hollow Fibre Diafiltration

Author: Spectrum Labs

Hollow Fibre Diafiltration is rapid alternative to traditional methods of nanoparticle purification like ultracentrifugation. Diafiltration can be used to purify a wide range of nanoparticles including liposomes, colloids, magnetic particles and nanotubes...

Application Note: Reducing freeze dried product batch time

Application Note: The sterility of the ControLyo™ process: reducing freeze dried product batch time without compromise to system integrity

Author: Charles D. Dern P.E., Project Manager, SP Scientific

Controlled nucleation is the most significant new development in freeze drying in quite some time...

Whitepaper: Feasibility of a Rapid Microbiological Method for filterable raw materials

Whitepaper: Feasibility of a Rapid Microbiological Method for filterable raw materials

Author: Merck Millipore

The Milliflex® Quantum system (Merck Millipore) is a rapid method for the quantitative detection of contaminants in filterable samples...

Application Note: Are you seeing the whole picture with Raman?

Application Note: Are you seeing the whole picture with Raman?

Author: Ocean Optics BV

Raman spectroscopy offers a rapid, convenient method for positive identification of pharmaceutical products and their raw materials – on the manufacturing floor, in inventory, and at the shipping dock...

Application note: Clean room dehumidification ensures reliable test results

Application note: Clean room dehumidification ensures reliable test results

Author: Munters

Scandinavian Micro Biodevices (SMB), in Denmark, develops, produces and markets ‘point-of-care’ diagnostic systems for the veterinary market. In order to maintain a very low level of humidity in the clean room, a desiccant dehumidifier is required. An air quality of 5000m3/h must be maintained with the required condition of no more than 20% RH at 21°C, which corresponds to a water content of just three grams per kilogram of air. Munters' solution is an MX5000 dehumidification system with pre and post cooling...

Application Note: Morphological changes in drug compounds under the microscope

Application Note: Morphological changes in drug compounds under the microscope

Author: Dr. Matthias Wagner, Product Manager, Mettler Toledo

Heated crystalline pharmaceutical compounds undergo morphological changes that can be observed under a microscope. With hot-stage microscopy changes in melting points and ranges or crystallisation can be visualised for research and QC purposes in order to influence drug stability or effectiveness...

Application note: In-line PAT solutions for understanding and controlling fluidised bed granulation (FBG) processes

Application note: In-line PAT solutions for understanding and controlling fluidised bed granulation (FBG) processes

Author: Innopharma Labs

Determining CPP’s in DoE using Eyecon particle characteriser and Multieye Multipoint NIR...

 

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