Olga Laskina (Rap.ID)

Subvisible particle identification in protein-based formulations by Raman spectroscopy

29 June 2017 | By Markus Lankers (Rap.ID), Olga Laskina (Rap.ID), Oliver Valet (Rap.ID)

Subvisible particles in protein-based formulations can have different origins. Particles can be extrinsic (unexpected foreign material), intrinsic (from the production environment or primary packaging), and inherent (from the formulation). It is important that inherent particles (protein agglomerates) are distinguished from the other two types and that the extrinsic and intrinsic…