Recommended

Considering joining us at our online summit? Attend our short LinkedIn live preview to discover the event’s exclusive insights from renowned industry leaders, scientists, and regulatory professionals! Register now.
Discover the latest breakthroughs in environmental monitoring when you download our latest brand report! Get your free copy today!
EPR’s latest Pharma Horizons report explores the latest advances in cell and gene therapy for quality control, manufacturing, analytical development and more – READ MORE
LinkedIn Live: Breaking down silos: how digital tools boost pharma manufacturing. Join us on 17th June at 2pm BST to discover practical approaches to address top barriers to digital transformation.
Register for this webinar to learn about impurity control in pharmaceutical waters! Coming soon!

List view / Grid view

Nanoparticles

 

Figure 1 Schematic illustration of a particle stabilised by a steric stabiliser. Note that it has been reported that both the degree of adsorption and the density / thickness of the steric barrier are essential factors to mitigate freezing and drying stresses
Figure 1 Schematic illustration of a particle stabilised by a steric stabiliser. Note that it has been reported that both the degree of adsorption and the density / thickness of the steric barrier are essential factors to mitigate freezing and drying stresses
article

Stabilisation of nanoparticles during freeze drying: The difference to proteins

31 August 2011 | By Jakob Beirowski and Henning Gieseler, University of Erlangen-Nuremberg, Division of Pharmaceutics, Freeze Drying Focus Group

The underlying concept for the stabilisation of proteins during freeze drying is the formation of a glassy matrix in which the macromolecules remain isolated and immobilised. The concept relies on the so-called ‘vitrification hypothesis’ which assumes that the formation of an amorphous phase by lyoprotectants is mandatory to interact with…