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Application note: Determination of APIs in tablets by NIR-Spectroscopy

Posted: 15 December 2016 | | No comments yet

In this application note, Buchi discuss precise and robust calibration models for determining the active ingredient content of tablets…

In order to create a precise and robust calibration model for determining the active ingredient content of tablets, it is essential to choose a suitable calibration range.

This range should cover at least 75 -125% of the nominal content of the active ingredient in 5% steps, in order to achieve sufficient accuracy of the calibration model. In the following the creation of two calibration models is described. These calibration models were created using two different types of tablets. Captopril 25 mg tablets are clover-leaf shaped tablets and have an active ingredient content of 25 mg and a total weight of 160 mg. Ramipril 2.5 mg tablets are oblong (4mm x 8mm), are engraved on one side, contain 2.5 mg active ingredient and have a total weight of 80 mg.

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