- Cancer Biology & Biomarkers
- Chromatography & Mass Spectrometry
- Contract Research, Clinical Trials and Outsourcing
- Drug Discovery
- Drug Targets
- Flow Cytometry
- Informatics & Lab Automation
- Ingredients, Excipients and Dosages
- Microbiology & RMMs
- NIR, PAT & QbD
- Raman Spectroscopy
- Screening, Assays & High-Content Analysis
- Thermal Processing
- Events & Workshops
Graphene boosts chemotherapy treatment effect
9 July 2015 • Author: Victoria White
Chemotherapy treatment usually involves the patient receiving medicine through an intravenous catheter.
These catheters are treated with a silver coating which is antibacterial, preventing bacterial growth and unwanted infections during a treatment.
Researchers at the Norwegian University of Science and Technology’s (NTNU) Department of Physics are now studying what happens when different drugs come in contact with this silver coating.
“We wanted to find potential problem sources in the tubes used in intravenous catheters. An interaction between the coating and the drugs was one possibility. Chemotherapy drugs are active substances, so it isn’t hard to imagine that the medicine could react with the silver,” explained Justin Wells, an associate professor of physics at NTNU.
The team used x-ray photoemission spectroscopy (XPS) to look at the surface chemistry of one of the most commonly used chemotherapy drugs, 5-Fluorouracil (5-Fu), and the interaction between it and the type of silver coating found in medical equipment.
Silver breaks down chemotherapy drugs and creates hydrogen fluoride gas
They found that the antibacterial silver coating actually breaks down the drugs. Not only does this reduce the effect of a chemotherapy treatment, but it also creates hydrogen fluoride, a gas that can be harmful both to the patients and to the medical equipment.
“Reactions between chemotherapy drugs and other substances that the drugs come in contact with have, as far as we know, never been studied like this before,” Wells said. It has always been assumed that the drugs reach the body fully intact.
The group continued their studies with the XPS instrument, now examining how the same chemotherapy drugs reacted with graphene.
“Graphene is a non-reactive substance… So we thought that it might be a good combination with the chemotherapy drugs,” Wells explained.
And they were right- the drugs did not react with the graphene.
Graphene has already been suggested as a coating for medical equipment, and according to researchers, it should be possible to create thin layers of graphene designed for this use.
“This research has produced valuable information about the interaction between chemotherapy drugs and other substances that the medicine is in contact with. We hope that our work will contribute to making cancer treatment more effective, and that we can continue our work in this area,” Wells concluded.
The research findings are published in 2D Materials.
ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd Bachem AG Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) EUROGENTEC F.P.S. Food and Pharma Systems Srl IDBS JEOL Europe L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Panasonic Biomedical Sales Europe B.V. PerkinElmer Inc ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen Logistics