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Whitepapers/App Notes/Posters

Whitepaper: Characterising antibody-drug conjugates using micro pillar array columns combined with mass spectrometry (μPAC™-MS)

12 December 2018 | By

The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).

Whitepapers/App Notes/Posters

Application Note: Representative sampling of solids and turbid media in process raman spectroscopy

12 December 2018 | By

Raman spectroscopy is an analysis technique that provides a “molecular fingerprint” of the sample, enabling analysis of chemical composition and molecular structure without sample preparation. As a measurement technique, Raman imparts many benefits in applications from laboratory discoveries to feedback-control in manufacturing.

article

LC-MS based multi-attribute method for characterisation and QC testing of protein therapeutics

2 November 2018 | By

For several decades mass spectrometry (MS) has been used in the characterisation of protein pharmaceuticals.1-3 However, its use in the laboratory for quality control (QC) product release testing has been quite limited for a number of reasons, for example: instrument complexity and software are not readily amenable to validation, extensive…

webinar

Advances in automated performance verification for UV/VIS spectrophotometers

22 August 2018 | By Mettler-Toledo

Regulated environments require performance verification (qualification) of UV/VIS spectrophotometers on a regular basis. Instrument performance is the main factor directly affecting the accuracy and repeatability of measurements. Hence, it is important that this is regularly monitored and that documentary evidence is provided. Optical performance verification is conducted to the widely…

news

Metrohm acquires B&W Tek

31 July 2018 | By

Metrohm AG from Herisau, Switzerland and B&W Tek from Newark in Delaware, USA are pleased to announce the acquisition of B&W Tek’s Spectroscopy Solution Business, B&W Tek LLC, as well as several overseas subsidiaries. This acquisition contributes to the strategic growth of Metrohm enhancing the company’s capabilities to further develop…