- Cancer Biology & Biomarkers
- Chromatography & Mass Spectrometry
- Contract Research, Clinical Trials and Outsourcing
- Drug Discovery
- Drug Targets
- Flow Cytometry
- Informatics & Lab Automation
- Ingredients, Excipients and Dosages
- Microbiology & RMMs
- NIR, PAT & QbD
- Raman Spectroscopy
- Screening, Assays & High-Content Analysis
- Thermal Processing
NICE recommends trametinib plus dabrafenib in melanoma
3 May 2016 • Author: Victoria White, Digital Content Producer
The National Institute for Health and Care Excellence (NICE) has published final draft guidance recommending Novartis’ Mekinist (trametinib) in combination with Tafinlar (dabrafenib) to treat a type of skin cancer that has spread and can’t be surgically removed.
Patients with BRAF V600 mutation positive melanoma receiving the new treatment in two clinical trials survived an average of 6 months longer than those on other drugs.
Life expectancy for those with advanced melanoma is currently under two years. Melanoma accounted for around 1,750 deaths in 2012 in England, and 12,200 people were diagnosed in 2013.
Discount agreed between Novartis and the Department of Health
Commenting on the recommendation, Professor Carole Longson, Health Technology Evaluation Centre Director at NICE, said: “This combination treatment is the latest in a line of promising new drugs for advanced melanoma we have recommended that look set to significantly extend the life of people with the condition.
“I know from testimonies presented to the committee that patients and healthcare professionals alike will welcome this positive recommendation.”
The NHS will pay a reduced price for the drugs after a discount was agreed between Novartis and the Department of Health. The list price of trametinib with dabrafenib per patient per 28 days is £10,080.
In February NICE recommended nivolumab (Opdivo, Bristol Myers Squibb) for advanced melanoma. NICE has also issued two separate recommendations each for ipilimumab (YERVOY, Bristol-Myers Squibb) and pembrolizumab (Keytruda, Merck Sharp & Dohme) for advanced melanoma.
The final draft guidance is now with consultees, who have the opportunity to appeal against it.
ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd B&W Tek Bachem AG Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited Butterworth Laboratories Ltd CAPSUGEL NV Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) Eurofins BioPharma Product Testing EUROGENTEC F.P.S. Food and Pharma Systems Srl GE Analytical Instruments IDBS JEOL Europe Kaiser Optical Systems Inc. L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited Lonza MA Business Metrohm Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Ocean Optics Panasonic Biomedical Sales Europe B.V. Peak Scientific PerkinElmer Inc ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Viavi Solutions, Inc Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen Logistics