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Breast Cancer - Articles and news items

Life-extending breast cancer drug approved by NICE

Industry news / 3 November 2016 / Niamh Louise Marriott, Digital Content Producer

NICE has said eribulin, which is also called Halaven and made by Eisai, should be an option for people with locally advanced or metastatic breast cancer…

Large study shows older breast cancer patients have worse outcomes

Industry news / 13 October 2016 / Niamh Louise Marriott, Digital Content Producer

Results showed that mortality was higher in patients over 70 who were either not tested with Oncotype DX or had a recurrence score result greater than 18…

Daiichi Sankyo Phase 1 HER2-targeting antibody drug safe and effective to treat breast cancer

Industry news / 11 October 2016 / Niamh Louise Marriott, Digital Content Producer

DS-8201a is an investigational antibody drug conjugate comprised of a humanised anti-HER2 antibody attached by a peptide linker to a novel topoisomerase…

Novartis’ HR+/HER2- advanced breast cancer trial gives superior progression-free survival

Industry news / 10 October 2016 / Niamh Louise Marriott, Digital Content Producer

The results demonstrate that LEE011 plus letrozole reduced the risk of death or progression by 44%. The combination significantly improved PFS across…

Gene activity linked to breast cancer survival

Industry news / 18 August 2016 / The Institute of Cancer Research, London

In a study of nearly 2000 patients, researchers found that women whose tumours had high F12 activity and low STC2 activity had a 32% chance of dying within 10 years, whereas those with low F12 activity and high STC2 activity had only a 10% chance of dying…

Lilly and Boehringer Ingelheim take on metastatic breast cancer

Industry news / 13 July 2016 / Victoria White, Digital Content Producer

Lilly and Boehringer Ingelheim are to collaborate on a Phase Ib study of abemaciclib and BI 836845 in patients with HR+, HER2- metastatic breast cancer…

Denosumab may prevent breast cancer in women with BRCA1 gene mutation

Industry news / 20 June 2016 / Victoria White, Digital Content Producer

Researchers have discovered that an existing medication, denosumab, may prevent breast cancer in women carrying a faulty BRCA1 gene…

Faslodex demonstrates superiority to Arimidex in Phase III study

Industry news / 27 May 2016 / Victoria White, Digital Content Producer

The Phase III FALCON trial compared Faslodex to Arimidex for the treatment of locally-advanced or metastatic breast cancer, in post-menopausal women…

Breast-cancer

Long term benefits of breast cancer drug pertuzumab too uncertain says NICE

Industry news / 20 May 2016 / Katie Sadler

NICE has announced it will not be recommending pertuzumab to treat HER2-positive breast cancer because it is uncertain of the long term benefits for patients.

The vascular remodelling effects of eribulin in advanced breast cancer

Industry news / 12 May 2016 / Victoria White, Digital Content Producer

Newly published data validate the distinct vascular remodelling activity of Halaven (eribulin) compared to bevacizumab in breast tumour tissue…

Positive top-line results from the Phase III PALOMA-2 trial

Industry news / 20 April 2016 / Victoria White, Digital Content Producer

Pfizer has announced positive top-line results from the Phase III PALOMA-2 trial for Ibrance (palbociclib) in breast cancer…

Lapatinib and trastuzumab shrinks HER2+ breast cancers within 11 days

Industry news / 11 March 2016 / Victoria White

A trial has shown that lapatinib plus trastuzumab before surgery shrinks and may even destroy tumours in women with HER2+ breast cancer within 11 days. The EPHOS B trial studied 257 women with HER2 positive breast cancer in the short gap between initial diagnosis and surgery to remove their tumours. The trial set out to study the biological effects of the drug combination by measuring biological markers of cellular proliferation after 11 days of therapy…

 

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