Mass Spectrometry: In-Depth Focus 2014
Posted: 15 April 2014 | European Pharmaceutical Review
In this free-to-view Mass Spectrometry In-Depth Focus: Some tricks and tools for structural characterisation of natural products using Electrospray mass spectrometry, Mass spectrometry in the biopharmaceutical industry: from the mundane to the cutting edge, and Mass Spectrometry roundtable…
- Electrospray mass spectrometry: some tricks and tools for structural characterisation of natural products
(Authors: Paul J. Gates, School of Chemistry, University of Bristol)
Electrospray mass spectrometry is often coupled to liquid chromatography (LC-MS) and tandem mass spectrometry (MS/MS) for the analysis of potential drug targets from complex matrices (plant extracts for example). But this requires some knowledge of the way the target molecules fragment in MS/MS and some understanding of gas-phase fragmentation. Natural products offer some interesting challenges to structural characterisation by MS/MS. With peptides, the cleavage points are well established to be at (or neighbouring) the amide bonds and, although side chain fragmentation can add a layer of complexity, peptide sequencing, as a result, can often be automated…
- Mass Spectrometry Roundtable
(Participants: Stéphane Moreau, EU Product Manager MS & Life Sciences, Shimadzu Europa GmbH and Don Richards, Director of Integrated Characterisation Solutions, Bruker Daltonik GmbH)
Moderated by Andras Szeitz, Manager, Mass Spectrometry Facility, Faculty of Pharmaceutical Sciences, University of British Columbia
- Mass spectrometry in the biopharmaceutical industry: from the mundane to the cutting edge
(Author: Ioannis Papayannopoulos, Principal Scientist, Targanox)
The use of mass spectrometry in the biopharmaceutical industry has increased steadily during the past several decades. Initially applied to small molecule drugs for the confirmation of their structure, the use of the technology quickly expanded to cover the detection, characterisation and quantitation of process impurities and metabolites. Developments in ionisation techniques and mass analysers have enabled the use of mass spectrometry to the analysis of large, labile molecules such as peptides and proteins, initially as a tool for the characterisation of novel therapeutic proteins, subsequently to be used in monitoring and adjusting process development and manufacturing parameters and for characterising final product…
- Show Preview: 62nd ASMS Conference on Mass Spectrometry and Allied Topics
The 62nd ASMS Conference on Mass Spectrometry and Allied Topics will take place from 15 – 19 June 2014 at the Baltimore Convention Center, Baltimore, USA. Over 6,500 scientists will attend one of the most dynamic scientific conferences in the world, where approximately 3,000 papers will be presented as posters and discussions. Sponsored by the American Society for Mass Spectrometry, the event will be further heightened by participation of ASMS Corporate Members.
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