Informatics & Lab Automation

A selection of articles from European Pharmaceutical Review covering Informatics, eLN and Lab Automation:


How digital transformation drives change and collaboration in the laboratory

8 September 2016  •  Dassault Systèmes BIOVIA

This webinar shows how Lonza’s Specialty Ingredients sector successfully digitised and unified their global research operations with BIOVIA solutions...

Informatics Supplement

Informatics in-depth focus 2015

3 September 2015  •  European Pharmaceutical Review

In this Informatics in-depth focus: Informatics in 2025, Methods for the detection of drug-drug interactions in text & Computational approaches to mutagenicity assessments of impurities: in silico methods...

Informatics Supplement

Informatics: In-depth focus 2014

5 September 2014  •  Brittany L. Melton, John Trigg

In this free-to-view Informatics in-depth focus: Reviewing the roles and opportunities for informatics in pharmacovigilance, Laboratory informatics: a wind of change?

Cindy Novak-DeLaurell

Mitigating the common pitfalls of LIMS implementation

19 February 2014  •  Cindy Novak-DeLaurell, Systems Application Consultant, Allergan

Over the past 20 years, I have participated in numerous LIMS implementation projects in a variety of roles. I have participated as a subject matter expert (SME), validation coordinator, programmer, System Administrator and technical representative, and have worked both in the laboratories and IS during these projects; gaining an insight to both perspectives. Over time, I have come to realise that all projects will experience common pitfalls that impact the success of the project. The information presented below is based on my personal experiences across all LIMS projects in which I’ve participated...

Diana Russom, Department of Information Technology Systems, Beckman Research Institute of the City of Hope

Informatics: The use of LIMS in the management of translational research and pilot manufacturing operations

22 October 2013  •  Diana Russom (Department of Information Technology Systems, Beckman Research Institute of the City of Hope) / Amira Ahmed and Nancy Gonzalez (Laboratory for Cellular Medicine, Beckman Research Institute of the City of Hope) / David L. DiGiusto (Laboratory for Cellular Medicine and Department of Virology, Beckman Research Institute of the City of Hope)

The volume of data generated in modern medical research centres is growing exponentially and becoming more diverse as advancements in automation and biotechnology transform the basic operations of these laboratories and clinics. Patient care and laboratory instrumentation generate data at a rate that rapidly outpaces the ability to track and process information with traditional (manual) methods. We found that a robust electronic information management system is essential to maintain control over operations in a dependable and compliant fashion. Over the last seven years, we have developed and implemented a Laboratory Information Management (LIMS) system in our academic translational research laboratory and have since expanded to related research and clinical manufacturing operations. We describe examples of how the LIMS system was developed, implemented and how workflows were streamlined; and time and labour were reduced for routine data collection and management requirements, all while ensuring compliance with federal and state regulations.

EPR Informatics Supplement 2013

Informatics: In-depth focus 2013

21 August 2013  •  Eva Bürén (Karolinska Institutet Biobank), Michael H. Elliott (Atrium Research)

Using LIMS for biobanking and implementing LIMS for research.
Biologics development and ELN: A good match?
Informatics Roundtable.

Informatics In-depth focus 2012

Informatics – In-depth focus 2012

2 September 2012  •  European Pharmaceutical Review

Developing Informatics for the pharmaceutical industry.
Rolling out a biology ELN at UCB Pharma.
Ask the Informatics experts.
Laboratory Informatics – Out of the fog and into the cloud?

Drug discovery assays for the histone deacetylase class of enzymes

Implementing electronic laboratory notebooks to improve the efficiency of pre-clinical drug discovery

13 December 2011  •  Sheraz Gul, Vice President and Head of Biology, European ScreeningPort GmbH

The pre-clinical phase of drug discovery spans a period in the region of five years and requires contributions from multi-disciplinary teams often working at different sites. These teams can generate significant amounts of data which are processed using standard as well as specialist software. The recording of a substantial amount of project related experimental work has historically been performed using paper-based laboratory notebooks completed manually with all files usually being stored locally. This scenario poses a variety of issues such as delayed access to important information to the project team members which could ultimately reduce its efficiency and thus increase the time taken to complete the project. These paper-based notebooks are now being replaced by an electronic laboratory notebook (eLNB) within research laboratories in industry and academia. Such software allows the documentation of experimental data and its sharing within the multi-disciplinary research team and would be expected to improve data integrity, reduce the time to complete the project and improve communication. This article discusses some of the advantages that would be expected to be achieved upon implementing an eLNB in pre-clinical drug discovery.

eLN supplement 2011

31 August 2011  •  John Wise (Executive Director, Pistoia Alliance), John Leonard, David Fletcher, Matthew Harrison and Ian Menzies (Pharmaceutical Development, AstraZeneca), Alexander Botzki (eLN Project Officer, VIB)

Introduction: eLNs - An essential productivity tool - but which one to use?
Using an eLN to create GMP compliant records for drug substance manufacture.
Implementation of an electronic lab notebook system at VIB.
eLN sponsors roundtable (featuring Accelrys, IDBS, AgileBio, Agilent, LabWare Europe, Waters).

Automation in the Pharmaceutical Industry

Trends in laboratory automation: From speed and simplicity to flexibility and information content

24 June 2010  •  Fernando A. Ramon Olayo, Manager, GlaxoSmithKline

The pharmaceutical industry has significantly influenced laboratory automation trends in the past two decades. The need to screen large collections of chemical entities in a short time with minimised consumption of reagents has driven a strong demand of parallelisation, automation, simplification and miniaturisation solutions from the suppliers of instruments, labware and assay technologies. Currently, the levels of automation and miniaturisation seem to have reached a plateau and the new paradigms are flexibility and information content.


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