Raman Spectroscopy

A selection of articles from European Pharmaceutical Review covering Raman Spectroscopy and Non-Destructive Material Identificiation:


Raman In-depth focus 2016

Raman: In-Depth Focus 2016

29 February 2016  •  European Pharmaceutical Review

Raman as a valuable tool in high-throughput screening; Use of Raman in analysing polymorphism in pharmaceutical drugs; Upcoming Raman calibration standards; Raman roundtable

Upcoming Raman calibration standards

29 February 2016  •  Kerstin Barr, Product Manager, Thermo Fisher Scientific

In this article, Kerstin Barr, Product Manager for handheld Raman instruments at Thermo Fisher Scientific, comments on the revised tolerances...

Raman Spectroscopy In-depth focus

Raman Spectroscopy: In-depth Focus 2015

22 October 2015  •  Sulaf Assi, Sulayman A. Oladepo, Hui Wang, David Barona, Reinhard Vehring

Identification of counterfeit drugs using dual laser handheld Raman; Low-frequency shift Raman spectroscopy of pharmaceutical respirable powders; Raman Roundtable

Revolutionising Raman with the transmission technique

Revolutionising Raman with the transmission technique

3 July 2015  •  Julien Villaumié and Hilary Jeffreys, Actavis

All regulatory agencies require that manufacturers accurately determine the amount of drug in a medicinal product so that the product can be deemed fit for patients. This forms part of batch release testing performed by Quality Control (QC) laboratories. The drug assay and/or content uniformity of the dosage units is typically performed by a wet chemistry technique that has not significantly changed in the industry for four decades. High performance liquid chromatography (HPLC) is widely used by laboratories for that purpose, and automated sample preparation systems are available. But there are drawbacks to these methods. This article explores how Transmission Raman now has the potential to revolutionise the release testing of pharmaceutical product in a QC laboratory...

Raman Spectroscopy in-depth focus

Raman Spectroscopy: In-depth focus 2014

5 November 2014  •  Michael J. Miller, Deborah Gessell-Lee, Oliver Gordon, Joe Johnston, Neil Lewis, Jeanne Mateffy, Jeffrey W. Weber

Sulaf Assi discusses the investigation of medicine quality using handheld Raman spectroscopy, a look at Raman hyperspectral imaging, plus Raman roundtable...

Multivariate Calibration Maintenance

The flexibility of regularisation processes for multivariate calibration maintenance

5 September 2014  •  Dr. John H. Kalivas, Editor for the Journal of Chemometrics and Applied Spectroscopy.

In the pharmaceutical industry, it is necessary to control, in a tight range, the active pharmaceutical ingredient (API) content of products, e.g., tablets or other powder blends. Thus, the API content needs to be continuously monitored. Preferably, analysis for the API content should be in-line (on site) allowing rapid and efficient quality control. It is well documented that spectroscopic methods, such as near-infrared (NIR) and Raman, in conjunction with multivariate calibration processes, can meet these goals under controlled conditions...

Raman Spectroscopy: In-depth focus 2014

10 April 2014  •  Sara J. Fraser, Keith C. Gordon, Sigrid Pieters, Yvan Vander Heyden, Thomas De Beer

Raman spectroscopy in the study of pharmaceuticals: the problems and solutions to sub-sampling and data analysis
Conformational state analysis of proteins by Raman spectroscopy: univariate and multivariate methods
Raman Roundtable

Raman spectroscopy: In-depth focus 2013

25 October 2013  •  Sulaf Assi (Bournemouth University), Xiaolin Cao (Amgen Inc.)

Raw material identification using dual laser handheld Raman spectroscopy.
Raman spectroscopy in support of biotherapeutic production: applications in protein formulation and purification
Raman Spectroscopy Roundtable.

Raman spectroscopy: an enabling tool for accelerating pharmaceutical discovery to development

Raman spectroscopy: an enabling tool for accelerating pharmaceutical discovery to development

20 August 2013  •  Chanda R. Yonzon, Atul Karande, Sai P. Chamarthy and Brent A. Donovan (Merck & Co. Inc)

Raman spectroscopy has emerged as the preeminent analytical tool for a number of applications within drug discovery and development. Advances in the instrumentation, sensor fabrication and data analysis have enabled the wider acceptance of Raman spectroscopy. In discovery, Raman spectroscopy is used to elucidate structural activity relationships and to optimise reaction conditions and associated parameters (such as polymorph and formulation screening) that impact scale-up required for the transfer of drug compounds from discovery to development.

Raman Supplement 2012

Non-destructive material identification: In-depth focus 2012

24 October 2012  •  European Pharmaceutical Review

An implementation perspective on handheld Raman spectrometers for the verification of material identity.
Portable Raman spectroscopy for pharmaceutical counterfeit detection.
Ask the Experts.

Applications of Raman, CARS and SRS imaging in dosage form development

26 April 2012  •  Clare Strachan, Senior Lecturer Pharmaceutical Sciences, School of Pharmacy, University of Otago

The use of Raman spectroscopy in pharmaceuticals has grown enormously since its appearance on the scene in the 1980s1-4. While typical Raman spectroscopy setups are able to provide chemical and physicochemical information about the sample on the bulk level, most solid samples in the pharmaceutical setting may not be assumed to be homogenous, and many critical quality attributes, such as drug release for example, depend on component distribution. Thus, obtaining chemically and spatially resolved information about pharmaceutical samples is pertinent. Since Raman microscopy imaging made its debut in the pharmaceutical setting, the range of pharmaceutical applications for which the technique has been used has continued to grow5-7. Briefly, Raman spectroscopy involves the detection of inelastic scattering of light associated with molecular vibrations. The resulting photons have a longer (Stokes scattering) or shorter wavelength (anti-Stokes scattering) than the incident photons. In the most common setup (with spontaneous Raman scattering), the Stokes effect is detected since it is stronger. Raman spectroscopy is related to (near- and mid-) infrared spectroscopy since both techniques probe molecular vibrations, but there are several practical differences, which are due to the different molecular phenomena behind Raman scattering (polarisability change during vibration) and infrared absorption (dipole moment change, for more detail see e.g.8,9,5 for a brief explanation). While near-infrared and mid-infrared micro - scopy may also be used to gain chemically and spatially resolved information about samples, Raman microscopy has some advantages which include:

Raman Supplement 2011

Raman supplement 2011

24 October 2011  •  Alain Hédoux, Klara Dégardin, Yves Roggo

Solid state transformations of APIS during manufacturing by Raman analysis of pharmaceutical molecules and dosage forms.
Detection, determination of chemical composition and chemical profiling of counterfeit medicines.

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