Astellas and Chromocell to develop neuropathic pain treatments

Posted: 30 September 2015 |

Astellas has obtained worldwide rights to commercialise Chromocell’s lead compound, CC8464 – an oral, peripherally-acting inhibitor of NaV1.7…

Astellas and Chromocell have entered into a license and collaboration agreement for the development and commercialisation of therapeutics to treat neuropathic and other pain conditions.


As part of the agreement, Astellas obtains worldwide rights to commercialise CC8464 and back-up drug candidates to treat pain that have been identified through Chromocell’s Chromovert technology platform. Chromocell will receive $15 million as an up-front payment and is eligible to receive over $500 million as well as double digit royalties on sales if CC8464 is successfully commercialised. Chromocell will conduct all development of CC8464 through the initial Phase 2a proof-of-concept clinical trial in neuropathic pain. Astellas will lead all further development activities through to commercialisation of CC8464 for the treatment of peripheral neuropathic pain. Aside from those development activities, Chromocell may propose, and may initiate, studies for certain additional indications such as rare diseases and non-oral formulations of the drug candidate. Astellas has the right to opt-in for development for such additional indications, which triggers additional payments to Chromocell.

Chromocell’s CC8464 inhibits NaV1.7 – an ion channel involved in the transmission of pain

Chromocell’s lead compound, CC8464, is an oral, peripherally-acting inhibitor of NaV1.7 which may prove to be efficacious in several large unmet or poorly served chronic pain markets as well as rare, currently untreated diseases. Chromocell anticipates filing an IND for CC8464 in early 2016. 

Kenji Yasukawa, Ph.D., Senior Vice President and Chief Strategy Officer of Astellas, said, “Astellas expects to provide a new therapeutic option to neuropathic and other pain conditions with high unmet medical needs by the collaboration to develop CC8464, and to make further contributions to the treatment of patients with pain conditions.”

Christian Kopfli, Chief Executive Officer of Chromocell said, “We are delighted to enter a collaboration with Astellas for the development and commercialisation of CC8464 as patients still lack adequate therapeutics against pain. Astellas’ leadership and commitment in the pain space make this an ideal partnership. Chromovert technology enables effective drug discovery with complex targets like NaV1.7, opening up opportunities in areas with unmet medical needs. We look forward to working closely with Astellas in the development of CC8464 to provide innovative therapeutics to patients with pain conditions.”