Thermo Fisher Scientific Inc., the world leader in serving science, today introduced the Thermo Scientific Q Exactive high-performance benchtop quadrupole-Orbitrap LC-MS/MS. It is the first commercially available instrument to bring together quadrupole precursor selection and high-resolution accurate mass (HR/AM) Orbitrap mass analysis to deliver high confidence quantitative and qualitative (quan/qual) workflows.
Thermo Fisher Scientific Debuts High-Performance Benchtop Quadrupole-Orbitrap Mass Spectrometer at ASMS 2011
With innovative HR/AM Quanfirmation capability, the Q Exactive mass spectrometer makes it possible to identify, quantify and confirm more trace-level metabolites, contaminants, peptides and proteins in complex mixtures-in one analytical run. Unlike other technologies, high confidence results are obtained without sacrificing MS/MS sensitivity, mass resolution or quantitative reproducibility. The Q Exactive system will be on display at Thermo Scientific Booth 110 or the Thermo Scientific hospitality suite at the Hyatt Regency in Centennial Ballroom D during the 59th ASMS Conference on Mass Spectrometry and Allied Topics, from June 5-9 in Denver.
This report addresses the key factors shaping pharmaceutical formulation, including regulation, QC and analysis.
Access the full report now to discover the techniques, tools and innovations that are transforming pharmaceutical formulation, and learn how to position your organisation for long-term success.
What you’ll discover:
Key trends shaping the pharmaceutical formulation sector
Innovations leading progress in pharmaceutical formulation and how senior professionals can harness their benefits
Considerations and best practices when utilising QbD during formulation of oral solid dosage forms
Can’t attend live? No worries – register to receive the recording post-event.
“The Q Exactive system offers a novel benchtop LC-MS/MS capability we call Quanfirmation, a capability encompassing compound identification, quantitation and confirmation.” said Ian Jardine, vice president of global R&D, Thermo Fisher Scientific. “For laboratories performing protein identification, metabolism, forensic toxicology and food safety analyses, Quanfirmation makes it possible to perform time-saving, single-run quan/qual workflows routinely.”
Powered by Orbitrap technology, the Q Exactive system delivers ultra high resolution and exceptional mass accuracy, enabling high confidence identifications and retrospective data analysis. Fast scanning and spectral multiplexing ensure the system is fully compatible with UHPLC separations.
Fast positive-negative scan-to-scan polarity switching enables detection of a wide range of compound types in a single analysis.
The Q Exactive high performance benchtop quadrupole-Orbitrap LC-MS/MS extends the capabilities of the Thermo Scientific Exactive family of Orbitrap systems with significant new design innovations:
New ion source optics increase sensitivity up to five-fold.
Integrated quadrupole mass filter enables precursor ion selection. True MS/MS fragmentation occurs in the higher energy collisional induced dissociation (HCD) cell prior to Orbitrap HR/AM detection.
Advanced signal processing increases system resolving power to 140,000 FWHM in full-scan mode and maximum scan speed
New C-Trap ion optics and HCD collision cell offer fast HCD MS/MS scanning and improve low-mass ion transmission, thereby enhancing sensitivity and quantitative performance, particularly for experiments that use isobaric labeling.
Multiplexed detection increases overall system duty cycle for compatibility with UHPLC. Up to ten precursor ions can be collected and stored prior to simultaneous detection in the Orbitrap.
Together these features make the Q Exactive system the ideal choice for unambiguous Quanfirmation — the identification, quantitation, and confirmation — of hundreds of trace-level components in complex matrices, in a single analytical run. And, the system supports time-saving workflows for emerging applications, such as food safety and forensic toxicology, that employ general extraction methodologies resulting in very complex sample matrices for subsequent analysis by LC-MS. With the Q Exactive system, laboratories can identify more proteins, more metabolites and more contaminants with greater confidence.
For more information about the Q Exactive system as well as other new Thermo Scientific products, please visit the Thermo Scientific booth 110 at ASMS 2011. Alternatively, please contact your local sales person, or call (800) 532-4752, e-mail [email protected], or visit www.thermoscientific.com/qexactive.
Thermo Fisher’s innovative Technology Refresh program allows companies to invest with confidence in the latest instruments for the lab at the lowest total cost. Technological advances in Mass Spectrometry occur on average every 18 months. Technology Refresh helps safeguard against analytical instrument obsolescence by offering financing for a new mass spectrometer with a 36-month operating lease, fixed monthly payments, and the option to upgrade to the latest available technology at the 24th month of the term.
The program applies to new acquisitions, but can be modified for trade-ins and replacements for current aging equipment. For more information, contact the Thermo Fisher Financial Services team at (800) 986-9731.
This website uses cookies to enable, optimise and analyse site operations, as well as to provide personalised content and allow you to connect to social media. By clicking "I agree" you consent to the use of cookies for non-essential functions and the related processing of personal data. You can adjust your cookie and associated data processing preferences at any time via our "Cookie Settings". Please view our Cookie Policy to learn more about the use of cookies on our website.
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorised as ”Necessary” are stored on your browser as they are as essential for the working of basic functionalities of the website. For our other types of cookies “Advertising & Targeting”, “Analytics” and “Performance”, these help us analyse and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these different types of cookies. But opting out of some of these cookies may have an effect on your browsing experience. You can adjust the available sliders to ‘Enabled’ or ‘Disabled’, then click ‘Save and Accept’. View our Cookie Policy page.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Cookie
Description
cookielawinfo-checkbox-advertising-targeting
The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".
cookielawinfo-checkbox-analytics
This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".
cookielawinfo-checkbox-necessary
This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance
This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Performance".
PHPSESSID
This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
viewed_cookie_policy
The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
zmember_logged
This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.
Performance cookies are includes cookies that deliver enhanced functionalities of the website, such as caching. These cookies do not store any personal information.
Cookie
Description
cf_ob_info
This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving “Always Online” until the cookie expires.
cf_use_ob
This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.
free_subscription_only
This session cookie is served by our membership/subscription system and controls which types of content you are able to access.
ls_smartpush
This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.
one_signal_sdk_db
This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.
YSC
This cookie is set by Youtube and is used to track the views of embedded videos.
Analytics cookies collect information about your use of the content, and in combination with previously collected information, are used to measure, understand, and report on your usage of this website.
Cookie
Description
bcookie
This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.
GPS
This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location
lang
This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.
lidc
This cookie is set by LinkedIn and used for routing.
lissc
This cookie is set by LinkedIn share Buttons and ad tags.
vuid
We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.
wow.anonymousId
This cookie is set by Spotler and tracks an anonymous visitor ID.
wow.schedule
This cookie is set by Spotler and enables it to track the Load Balance Session Queue.
wow.session
This cookie is set by Spotler to track the Internet Information Services (IIS) session state.
wow.utmvalues
This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.
_ga
This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.
_gat
This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.
_gid
This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.
Advertising and targeting cookies help us provide our visitors with relevant ads and marketing campaigns.
Cookie
Description
advanced_ads_browser_width
This cookie is set by Advanced Ads and measures the browser width.
advanced_ads_page_impressions
This cookie is set by Advanced Ads and measures the number of previous page impressions.
advanced_ads_pro_server_info
This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.
advanced_ads_pro_visitor_referrer
This cookie is set by Advanced Ads and sets the referrer URL.
bscookie
This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.
IDE
This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.
li_sugr
This cookie is set by LinkedIn and is used for tracking.
UserMatchHistory
This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences.
VISITOR_INFO1_LIVE
This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.